Intestinal IMINO transporter SIT1 is not expressed in human newborns

American Journal of Physiology. Gastrointestinal and Liver Physiology
C MeierRaphael N Vuille-dit-Bille

Abstract

The expression of amino acid transporters in small intestine epithelia of human newborns has not been studied yet. It is further not known whether the maturation of imino acid (proline) transport is delayed as in the kidney proximal tubule. The possibility to obtain small intestinal tissue from patients undergoing surgery for jejunal or ileal atresia during their first days after birth was used to address these questions. As control, adult terminal ileum tissue was sampled during routine endoscopies. Gene expression of luminal imino and amino acid transporter SIT1 (SLC6A20) was approximately threefold lower in newborns versus adults. mRNA levels of all other luminal and basolateral amino acid transporters and accessory proteins tested were similar in newborn mucosa compared with adults. At the protein level, the major luminal neutral amino acid transporter B0AT1 (SLC6A19) and its accessory protein angiotensin-converting enzyme 2 were shown by immunofluorescence to be expressed similarly in newborns and in adults. SIT1 protein was not detectable in the small intestine of human newborns, in contrast to adults. The morphology of newborn intestinal mucosa proximal and distal to the obstruction was generally normal, but a decreased ...Continue Reading

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Citations

Jul 2, 2019·Journal of Pediatric Gastroenterology and Nutrition·Chantal Florence MeierRaphael Nicolas Vuille-Dit-Bille
Jul 7, 2020·Amino Acids·Raphael N Vuille-Dit-BilleLaura C Guglielmetti
Mar 14, 2020·International Journal of Molecular Sciences·Martina ChiuOvidio Bussolati
Nov 4, 2020·Clinical Science·Simone M R CamargoFrançois Verrey
Feb 20, 2021·Human Genetics·Ana I Hernández CorderoDon D Sin
Mar 7, 2021·Children·Isabella N BielickiRaphael N Vuille-Dit-Bille
Mar 29, 2021·Advanced Drug Delivery Reviews·John P GleesonKathryn A Whitehead
Oct 21, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Stefano MaricRaphael Nicolas Vuille-Dit-Bille

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Methods Mentioned

BETA
confocal microscopy
X-ray
biopsies
PCR

Software Mentioned

Graphpad Prism
Adobe Photoshop
Imaris
GraphPad

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