PMID: 8598428Dec 1, 1995Paper

Intestinal immune function is unaffected by parenteral nutrition in man

Journal of the American College of Nutrition
A L BuchmanM E Ament

Abstract

Animal studies have demonstrated intestinal immunoglobulin production is decreased when luminal nutrition is withheld and nutrition is provided solely on the basis of total parenteral nutrition (TPN). Eight normal volunteers were hospitalized in the Clinical Research Center for three weeks. The subjects received TPN as an exclusive means of nutritional support for 14 days followed by 5 days of enteral feeding with either standard or a glutamine- and arginine-supplemented formula in which the protein source was primarily free amino acids and peptides. Endoscopic jejunal biopsies obtained before and after TPN and following enteral refeeding were evaluated by immunofluorescence for the number of IgA, IgM and IgG-producing cells; T and B cells as well as intraepithelial and lamina propria lymphocytes were also counted. Serum immunoglobulins and the molecular forms of serum IgA were determined at the same intervals. The number of intestinal IgA-, IgM- and IgG-producing cells was unaffected by TPN (676 +/- 58 vs. 643 +/- 38, 101 +/- 14 vs. 98 +/- 18, 10 +/- 1 vs. 11 +/- 2 per low power field). The total number of intestinal lymphocytes, and CD3+ lymphocytes in the intraepithelial area was unaffected by TPN (10.4 +/- 0.4 vs. 10.2 +/- ...Continue Reading

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Citations

Jun 4, 2008·Langenbeck's Archives of Surgery·Joshua L HermsenKenneth A Kudsk
Sep 12, 2000·Current Gastroenterology Reports·A L Buchman
May 3, 2002·Nutrition·John MacFie, Clare McNaught
May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·M E Keith, K N Jeejeebhoy
Dec 24, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Keisuke NoseDaniel H Teitelbaum
Jun 13, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F W GuglielmiA Francavilla
Apr 28, 2007·JPEN. Journal of Parenteral and Enteral Nutrition·Woodae Kang, Kenneth A Kudsk
May 3, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Matthew W RallsDaniel H Teitelbaum
May 20, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·T O Lipman
Dec 24, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·R R van der HulstP B Soeters
Apr 22, 2004·Journal of Clinical Gastroenterology·James S Scolapio
Jun 1, 1996·Journal of the American College of Nutrition·A L Buchman
Aug 17, 2002·Journal of Applied Physiology·Natalie Hiscock, Bente Klarlund Pedersen
Jul 14, 2001·The American Journal of Clinical Nutrition·A L Buchman
Jan 22, 2008·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Rajesh N KeswaniCarol E Semrad
Jan 1, 1997·Scandinavian Journal of Gastroenterology. Supplement·D J JenkinsS C Cunnane

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