Intestinal insulin resistance and aberrant production of apolipoprotein B48 lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia: evidence for activation of protein tyrosine phosphatase-1B, extracellular signal-related kinase, and sterol regulatory element-binding protein-1c in the fructose-fed hamster intestine

Diabetes
L M FedericoK Adeli

Abstract

Postprandial dyslipidemia is recognized as an important complication of insulin-resistant states, and recent evidence implicates intestinal lipoprotein overproduction as a causative factor. The mechanisms linking intestinal lipoprotein overproduction and aberrant insulin signaling in intestinal enterocytes are currently unknown. Intestinal insulin sensitivity and lipid metabolism were studied in a fructose-fed hamster model of insulin resistance and metabolic dyslipidemia. Intestinal lipoprotein production in chow-fed hamsters was responsive to the inhibitory effects of insulin, and a decrease in circulating levels of triglyceride-rich apolipoprotein (apo)B48-containing lipoproteins occurred 60 min after insulin administration. However, fructose-fed hamster intestine was not responsive to the insulin-induced downregulation of apoB48-lipoprotein production, suggesting insulin insensitivity at the level of the intestine. Enterocytes from the fructose-fed hamster exhibited normal activity of the insulin receptor but reduced levels of insulin receptor substrate-1 phosphorylation and mass and Akt protein mass. Conversely, the protein mass of the p110 subunit of phosphatidylinositol 3-kinase, protein tyrosine phosphatase-1B, and basa...Continue Reading

References

Sep 1, 1979·Circulation·D B Zilversmit
Dec 15, 1992·Biochimica Et Biophysica Acta·N LoirdighiE Levy
Sep 26, 1991·The New England Journal of Medicine·D E Moller, J S Flier
Jan 1, 1983·Annual Review of Physiology·J P Kane
Nov 30, 1994·Biochemical and Biophysical Research Communications·J D Sparks, C E Sparks
Feb 10, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·C TaggartG H Tomkin
Aug 26, 1998·Biochemical and Biophysical Research Communications·J KotzkaW Krone
Jan 15, 1999·Atherosclerosis·N MeroM R Taskinen
Apr 3, 1999·The Journal of Biological Chemistry·L Y QiaoX J Sun
Apr 20, 1999·JAMA : the Journal of the American Medical Association·K GuM I Harris
Aug 1, 2000·The Journal of Biological Chemistry·G RothD Müller-Wieland
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Yoshio NagaiAtsunori Kashiwagi
May 22, 2002·JAMA : the Journal of the American Medical Association·Joshua A BeckmanPeter Libby
Jun 22, 2002·Metabolism: Clinical and Experimental·Catherine PhillipsGerald H Tomkin
Dec 3, 2002·International Journal of Experimental Diabetes Research·Catherine PhillipsGerald H Tomkin
Mar 12, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaya HyakukokuKazuaki Shimamoto
Jan 6, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G S Hotamisligil
Feb 10, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M GrundyUNKNOWN American Heart Association
Jun 17, 2004·The Journal of Biological Chemistry·Eric D WernerSteven E Shoelson

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Citations

May 26, 2011·The Journal of Biological Chemistry·Thi Thu Trang TranIsabelle Niot
Feb 28, 2008·Current Opinion in Gastroenterology·Abigale Miller, Khosrow Adeli
May 8, 2008·Current Opinion in Lipidology·Khosrow Adeli, Gary F Lewis
Jan 14, 2011·Diabetes, Obesity & Metabolism·A J TremblayP Couture
Dec 14, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Scott D ZawiejaMariappan Muthuchamy
Oct 19, 2011·International Journal of Vascular Medicine·Gerald H Tomkin, Daphne Owens
Oct 3, 2008·The Journal of Clinical Investigation·Kevin Jon Williams
Jun 28, 2012·Journal of Lipid Research·Tomomi YamazakiOsamu Ezaki
Jan 27, 2009·PloS One·Olivier BéaslasVéronique Carrière
Feb 27, 2008·Journal of Clinical Biochemistry and Nutrition·Razieh JalalMorteza Behnam Rasuli
Mar 27, 2012·Journal of Clinical Biochemistry and Nutrition·Serhat OzdoğanBengü Çobanoğlu Simşek
Jul 7, 2010·Expert Review of Cardiovascular Therapy·Gerald H Tomkin
Sep 4, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Juan Patricio Nogueira, Fernando Daniel Brites
Oct 18, 2011·Biochimica Et Biophysica Acta·Changting Xiao, Gary F Lewis
Oct 19, 2011·Biochimica Et Biophysica Acta·Savitha Subramanian, Alan Chait
Aug 5, 2008·Atherosclerosis. Supplements·Hélène DuezGary F Lewis
Jul 26, 2008·Atherosclerosis. Supplements·Joanne HsiehKhosrow Adeli
Aug 12, 2008·Atherosclerosis. Supplements·Gerald H Tomkin
Sep 15, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Carolina Gutierrez-RepisoEduardo Garcia-Fuentes
May 15, 2015·Annual Review of Nutrition·Satya DashGary F Lewis
Apr 30, 2014·The Journal of Nutritional Biochemistry·M Miriam Jacome-SosaSpencer D Proctor
Dec 17, 2014·Acta Pharmacologica Sinica·Jiong YanWen Xie
Apr 4, 2017·Nutrients·Simon SteensonBarbara A Fielding
Jan 11, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Alain VeilleuxEmile Levy
Feb 7, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Juan-Patricio NogueiraRené Valéro
Apr 12, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Changting XiaoGary F Lewis
May 7, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Changting XiaoGary F Lewis

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