PMID: 16532221Mar 15, 2006Paper

Intestinal ischemia/reperfusion induces bronchial hyperreactivity and increases serum TNF-alpha in rats

Clinics
Marcio Jose Cristiano de ArrudaDario Birolini

Abstract

Intestinal or hepatic ischemia/reperfusion induces acute lung injury in animal models of multiple organ failure. Tumor necrosis factor (TNF)- alpha is involved in the underlying inflammatory mechanism of acute respiratory distress syndrome. Although the inflammatory cascade leading to acute respiratory distress syndrome has been extensively investigated, the mechanical components of acute respiratory distress syndrome are not fully understood. Our hypothesis is that splanchnic ischemia/reperfusion increases airway reactivity and serum TNF-alpha levels. To assess bronchial smooth muscle reactivity under methacholine stimulation, and to measure serum TNF-alpha levels following intestinal and/or hepatic ischemia/reperfusion in rats. Rats were subjected to 45 minutes of intestinal ischemia, or 20 minutes of hepatic ischemia, or to both (double ischemia), or sham procedures (control), followed by 120 minutes of reperfusion. The animals were then sacrificed, and the bronchial response to increasing methacholine molar concentrations (10(-7) to 3 x 10(-4)) was evaluated in an ex-vivo bronchial muscle preparation. Serum TNF-alpha was determined by the L929-cell bioassay. Bronchial response (g/100 mg tissue) showed increased reactivity t...Continue Reading

Citations

Jun 11, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Yumeng LiXian Shi
May 19, 2010·Biomarkers in Medicine·James KinrossJeremy K Nicholson
May 13, 2008·The Journal of Trauma·Luciana Borsoi MoraesDario Birolini

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