PMID: 1207417Dec 1, 1975Paper

Intestinal lipid absorption: evidence for an intrinsic defect of chylomicron secretion by normal rat distal intestine

Lipids
S M Sabesin, P R Holt

Abstract

Intracellular triglyceride accumulation and delayed chylomicron secretion were demonstrated in distal but not in proximal rat intestine following prolonged steady state fat absorption. After 1 and 4 hr of intraduodenal triolein infusion, the mucosal triglyceride content in distal intestinal segments was greatly increased compared with proximal segments. Electron microscopy at each time interval disclosed greater quantities of lipid droplets within the distal cells and these were much larger than the intracellular droplets in the proximal cells, some attaining an enormous size (9000 mum). When proximal and distal cells were compared at intervals after cessation of a 4 hr triolein infusion, the differences in intracellular lipid accumulation were also evident because, even after 6 hr the distal cells were still filled with large droplets, whereas the proximal cells were almost devoid of fat. These results indicate a basic cellular difference between proximal and distal intestine in the processing of fat and, in contrast to current concepts, suggest that defective chylomicron secretion is not necessarily associated with limited B-apoprotein availability.

References

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Citations

Dec 1, 1981·Digestive Diseases and Sciences·P R Holt, A A Dominguez
Jul 1, 1996·Digestive Diseases and Sciences·J PidlichA Gangl
Aug 1, 1987·Baillière's Clinical Endocrinology and Metabolism·J R Patsch
Jul 1, 1992·The Journal of Pharmacy and Pharmacology·T IchihashiH Yamada
Aug 1, 1977·The Journal of Clinical Investigation·C M Mansbach
Jan 1, 1994·The Journal of Clinical Investigation·A MahmoodD H Alpers
Jan 1, 1978·Scandinavian Journal of Gastroenterology·S B Clark, K R Norum
Jul 25, 2015·Journal of Animal Science and Biotechnology·Brian J KerrGerald C Shurson
Jun 28, 2005·Biochimica Et Biophysica Acta·Alexander A MironovAlvar Trucco
May 20, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alyssa S ZembroskiKimberly K Buhman
Aug 1, 1982·Metabolism: Clinical and Experimental·D H AlpersG Schonfeld

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