Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans

Frontiers in Physiology
Natalie L TrevaskisChristopher J H Porter

Abstract

The intestinal lymphatic system transports fluid, immune cells, dietary lipids, and highly lipophilic drugs from the intestine to the systemic circulation. These transport functions are important to health and when dysregulated contribute to pathology. This has generated significant interest in approaches to deliver drugs to the lymphatics. Most of the current understanding of intestinal lymph flow, and lymphatic lipid and drug transport rates, comes from in vitro studies and in vivo animal studies. In contrast, intestinal lymphatic transport studies in human subjects have been limited. Recently, three surgical patients had cannulation of the thoracic lymph duct for collection of lymph before and during a stepwise increase in enteral feed rate. We compared these data to studies where we previously enterally administered controlled quantities of lipid and the lipophilic drug halofantrine to mice, rats and dogs and collected lymph and blood (plasma). The collected lymph was analyzed to compare lymph flow rate, triglyceride (TG) and drug transport rates, and plasma was analyzed for drug concentrations, as a function of enteral lipid dose across species. Lymph flow rate, TG and drug transport increased with lipid administration in ...Continue Reading

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Citations

Aug 12, 2020·Lymphatic Research and Biology·Francine Blei
Jan 25, 2021·International Journal of Pharmaceutics·Given LeeNatalie L Trevaskis
Feb 22, 2021·Advanced Drug Delivery Reviews·Zahari VinarovPatrick Augustijns
Feb 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ruby KochappanChristopher J H Porter
Mar 24, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Zahari VinarovPatrick Augustijns
Aug 9, 2021·British Journal of Pharmacology·Pavel RyšánekOndřej Slanař
Oct 2, 2021·Computer Methods in Biomechanics and Biomedical Engineering·T D Jayathungage DonR J Clarke

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