Intestinal malabsorption of D-xylose: comparison of test modalities in patients with celiac disease

Scandinavian Journal of Gastroenterology
Kari TveitoViggo Skar

Abstract

The aim of the study was to compare three different D-xylose test modalities for small intestinal malabsorption, using patients with celiac disease and healthy persons as experimental models. Ninety-one untreated celiac patients, 98 treated celiac patients, and 43 healthy subjects performed the (13)C-D-xylose breath test. 1-h plasma D-xylose levels were measured in 48 untreated patients, 41 treated patients and 41 healthy controls. 4-h urine D-xylose excretion was measured in 47 untreated patients, 51 treated patients and 42 healthy controls. 100 mg of (13)C-D-xylose and 5 g of D-xylose were dissolved in 250 ml tap water and given orally. (13)CO(2) was measured in breath every 30 min for 4 h. Blood was sampled after 1 h, and urine collected after 4 h. Test sensitivity/specificity for celiac disease was 88%/84% with the (13)C-D-xylose breath test, 65%/71% with the 1-h plasma D-xylose test, and 55%/74% with the 4-h urine D-xylose excretion test. Breath test results improved significantly in the treated celiac group compared to untreated patients, but were not normalized compared to healthy controls. No difference was found between 1-h plasma D-xylose levels and 4-h urinary D-xylose excretion in treated celiac patients and healthy...Continue Reading

References

Feb 1, 1975·American Journal of Clinical Pathology·E L Krawitt, W L Beeken
Feb 1, 1991·Digestive Diseases and Sciences·Y PeledT Gilat
Jul 1, 1988·Gastroenterology·R M Craig, A J Atkinson
Dec 1, 1987·Scandinavian Journal of Gastroenterology·S Bodé, E Gudmand-Høyer
Jul 28, 1973·British Medical Journal·G E Sladen, P J Kumar
Feb 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·R GillbergB Swolin
Feb 1, 1981·Journal of Clinical Pathology·P G HillV I Mathan
Sep 9, 1999·Journal of Clinical Gastroenterology·R M Craig, E D Ehrenpreis
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ujjal PoddarKartar Singh
Jan 31, 2003·Gastrointestinal Endoscopy·Susie K LeePeter H R Green
Jul 23, 1959·The New England Journal of Medicine·C E BUTTERWORTHR SANTINI
Apr 7, 1962·British Medical Journal·I CHANARIN, M C BENNETT
Oct 7, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gail G PyleGary M Gray
May 1, 1937·The Journal of Clinical Investigation·O M Helmer, P J Fouts
Apr 24, 2007·Histopathology·M T BardellaV Villanacci
Sep 25, 2007·Scandinavian Journal of Gastroenterology·Kari TveitoViggo Skar
Apr 2, 2009·International Journal of Experimental Pathology·Danielle Mota Fontes AntunesGilberto Perez Cardoso

Citations

Jul 11, 2012·Clinical and Experimental Immunology·A CamarcaC Gianfrani
Oct 8, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard J Saad, William D Chey
Apr 24, 2013·The American Journal of Gastroenterology·Alberto Rubio-TapiaAmerican College of Gastroenterology
Jun 3, 2017·Microbial Ecology in Health and Disease·Steinar Traae BjørkhaugJørgen Valeur
Jul 29, 2020·Chinese Journal of Integrative Medicine·Yi XiaoJia Chen

Related Concepts

Breathalyzer Tests
Carbon Dioxide
Carbon Isotopes
Celiac Disease
High Pressure Liquid Chromatography Procedure
Differential Diagnosis
Intestinal Absorption
Intestines, Small
Retrospective Studies
Receiver Operating Characteristic

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.