Intestinal malabsorption of D-xylose: comparison of test modalities in patients with celiac disease

Scandinavian Journal of Gastroenterology
Kari TveitoViggo Skar

Abstract

The aim of the study was to compare three different D-xylose test modalities for small intestinal malabsorption, using patients with celiac disease and healthy persons as experimental models. Ninety-one untreated celiac patients, 98 treated celiac patients, and 43 healthy subjects performed the (13)C-D-xylose breath test. 1-h plasma D-xylose levels were measured in 48 untreated patients, 41 treated patients and 41 healthy controls. 4-h urine D-xylose excretion was measured in 47 untreated patients, 51 treated patients and 42 healthy controls. 100 mg of (13)C-D-xylose and 5 g of D-xylose were dissolved in 250 ml tap water and given orally. (13)CO(2) was measured in breath every 30 min for 4 h. Blood was sampled after 1 h, and urine collected after 4 h. Test sensitivity/specificity for celiac disease was 88%/84% with the (13)C-D-xylose breath test, 65%/71% with the 1-h plasma D-xylose test, and 55%/74% with the 4-h urine D-xylose excretion test. Breath test results improved significantly in the treated celiac group compared to untreated patients, but were not normalized compared to healthy controls. No difference was found between 1-h plasma D-xylose levels and 4-h urinary D-xylose excretion in treated celiac patients and healthy...Continue Reading

References

Feb 1, 1975·American Journal of Clinical Pathology·E L Krawitt, W L Beeken
Feb 1, 1991·Digestive Diseases and Sciences·Y PeledT Gilat
Jul 1, 1988·Gastroenterology·R M Craig, A J Atkinson
Dec 1, 1987·Scandinavian Journal of Gastroenterology·S Bodé, E Gudmand-Høyer
Jul 28, 1973·British Medical Journal·G E Sladen, P J Kumar
Feb 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·R GillbergB Swolin
Feb 1, 1981·Journal of Clinical Pathology·P G HillV I Mathan
Sep 9, 1999·Journal of Clinical Gastroenterology·R M Craig, E D Ehrenpreis
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ujjal PoddarKartar Singh
Jan 31, 2003·Gastrointestinal Endoscopy·Susie K LeePeter H R Green
Jul 23, 1959·The New England Journal of Medicine·C E BUTTERWORTHR SANTINI
Apr 7, 1962·British Medical Journal·I CHANARIN, M C BENNETT
Oct 7, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gail G PyleGary M Gray
May 1, 1937·The Journal of Clinical Investigation·O M Helmer, P J Fouts
Apr 24, 2007·Histopathology·M T BardellaV Villanacci
Sep 25, 2007·Scandinavian Journal of Gastroenterology·Kari TveitoViggo Skar
Apr 2, 2009·International Journal of Experimental Pathology·Danielle Mota Fontes AntunesGilberto Perez Cardoso

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Citations

Jul 11, 2012·Clinical and Experimental Immunology·A CamarcaC Gianfrani
Oct 8, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard J Saad, William D Chey
Apr 24, 2013·The American Journal of Gastroenterology·Alberto Rubio-TapiaUNKNOWN American College of Gastroenterology
Jun 3, 2017·Microbial Ecology in Health and Disease·Steinar Traae BjørkhaugJørgen Valeur
Jul 29, 2020·Chinese Journal of Integrative Medicine·Yi XiaoJia Chen

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