Intestinal mast cell response and mucosal defence against Strongyloides venezuelensis in interleukin-3-hyporesponsive mice

Parasite Immunology
T KobayashiY Nawa

Abstract

Recently several inbred strains of mice were found to be hyporesponsive to Interleukin (IL)-3 because of a 5-bp deletion in the intron 7 of the gene that encodes IL-3 receptor alpha subunit (IL-3R alpha). Due to this mutation, mast cells were not generated in vitro from bone marrow cells of these mice under the presence of IL-3. Intestinal mucosal mast cells, of which growth/differentiation is dependent on IL-3, are important effector cells in immune-mediated expulsion of intestinal nematodes, Stronglyoides spp. In the present study, therefore, we examined intestinal mast cell response and mucosal defence against Strongyloides venezuelensis in IL-3-hyporesponsive C58/J and A/J mice. After subcutaneous inoculation with 10,000 infective larvae, C58/J and IL-3-responsive C57BL/6 mice showed identical kinetic patterns of daily faecal egg output and intestinal mast cell response. When these mice were infected with 3000 L3 and, five weeks later, they were challenged by intraduodenal implantation of 800 S. venezuelensis adult worms, the timing of logarithmic decline of faecal egg count as well as intestinal mastocytosis was delayed for two days in C58/J mice. Kinetics of intestinal mastocytosis and faecal egg excretion after a primary...Continue Reading

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P W KincadeR A Good
Jul 1, 1994·Parasite Immunology·Y NawaF Uchiyama
Aug 1, 1993·International Journal for Parasitology·A I KhanY Nawa

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Citations

Jun 1, 2006·Clinical and Molecular Allergy : CMA·Raja S VadlamudiGuha Krishnaswamy
Mar 20, 2010·FEMS Immunology and Medical Microbiology·Eleuza R MachadoLúcia H Faccioli
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·John W FathmanKerri A Mowen
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eleuza R MachadoLúcia H Faccioli

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