Intestinal Microbiota in Animal Models of Inflammatory Diseases

ILAR Journal
Gabriele HörmannspergerDirk Haller

Abstract

The intestinal microbiota has long been known to play an important role in the maintenance of health. In addition, alterations of the intestinal microbiota have recently been associated with a range of immune-mediated and metabolic disorders. Characterizing the composition and functionality of the intestinal microbiota, unravelling relevant microbe-host interactions, and identifying disease-relevant microbes are therefore currently of major interest in scientific and medical communities. Experimental animal models for the respective diseases of interest are pivotal in order to address functional questions on microbe-host interaction and to clarify the clinical relevance of microbiome alterations associated with disease initiation and development. This review presents an overview of the outcomes of highly sophisticated experimental studies on microbe-host interaction in animal models of inflammatory diseases, with a focus on inflammatory bowel disease (IBD). We will address the advantages and drawbacks of analyzing microbe-host interaction in complex colonized animal models compared with gnotobiotic animal models using monoassociation, simplified microbial consortia (SMC), or microbial humanization.

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Citations

Dec 5, 2015·Frontiers in Immunology·Ludovica F ButtóDirk Haller
Mar 26, 2016·International Journal of Medical Microbiology : IJMM·Ludovica F Buttó, Dirk Haller
Apr 23, 2016·International Journal of Molecular Sciences·Mario MatijašićDonatella Verbanac
Oct 6, 2016·Scientific Reports·Jonas ZantowMichael Hust
May 18, 2019·Laboratory Animals·Marijana Basic, André Bleich
Sep 2, 2015·ILAR Journal·André Bleich, James G Fox
Mar 7, 2021·International Journal of Medical Microbiology : IJMM·Mohamed AhmedDirk Haller
Aug 6, 2021·Digestive Diseases and Sciences·Ioannis GeorgopoulosIoannis Papaconstantinou
Aug 10, 2021·World Journal of Gastroenterology : WJG·Xu-Xia HeJing-Nan Li

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