Intestinal mir-794 responds to nanopolystyrene by linking insulin and p38 MAPK signaling pathways in nematode Caenorhabditis elegans

Ecotoxicology and Environmental Safety
Yuexiu QiuDayong Wang

Abstract

Caenorhabditis elegans is sensitive to toxicity of environmental pollutants. The alteration in expression of mir-794, a microRNA (miRNA) molecule, mediated a protective response to nanopolystyene (100 nm) at predicted environmental concentration (1 μg/L) in nematodes. However, the underlying molecular basis for mir-794 function in regulating the response to nanopolystyrene remains largely unclear. In this study, we found that intestinal overexpression of mir-794 caused the susceptibility to nanopolystyrene toxicity, suggesting that mir-794 acted in the intestine to regulate the response to nanopolystyrene. Intestinal overexpression of mir-794 further decreased the expressions of daf-16 encoding a FOXO transcriptional factor in insulin signaling pathway, skn-1 encoding a Nrf transcriptional factor in p38 MAPK signaling pathway, and mdt-15 encoding a lipid metabolic sensor acting downstream of SKN-1 in nanopolystyrene exposed nematodes. Meanwhile, intestinal overexpression of mir-794 could suppress the resistance of nematodes overexpressing intestinal daf-16, skn-1, or mdt-15 containing the corresponding 3' untranslated region (3' UTR) to nanopolystyrene toxicity. Therefore, DAF-16, SKN-1, and MDT-15 acted as the downstream targe...Continue Reading

References

May 1, 1974·Genetics·S Brenner
Jun 21, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Maxwell C K LeungJoel N Meyer
May 2, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Qiuli WuDayong Wang
Jan 15, 2015·Archives of Toxicology·Hong W Yu, William C Cho
Sep 5, 2015·Environmental Science. Processes & Impacts·K MattssonT Cedervall
Jul 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Robin LenzTorkel Gissel Nielsen
Jul 28, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alison H HarrillBrian N Chorley
Aug 26, 2016·Archives of Toxicology·Klara Piletič, Tanja Kunej
Jun 1, 2017·Antioxidants & Redox Signaling·Verónica MiguelSantiago Lamas
Jul 10, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Belinda Shu Ee WongGyeong Hun Baeg
Dec 22, 2017·Environmental Science & Technology·Olubukola S AlimiNathalie Tufenkji
Jan 24, 2018·International Journal of Toxicology·Wendy J Bailey, Warren E Glaab
Mar 13, 2019·The Science of the Total Environment·Ee-Ling NgDeli Chen
Aug 20, 2019·Biological Trace Element Research·Shiyan GuZuoshun He
Nov 2, 2019·Environmental Pollution·Yunhan YangDayong Wang

❮ Previous
Next ❯

Citations

Oct 2, 2020·Ecotoxicology and Environmental Safety·Yunhan YangDayong Wang
Apr 24, 2021·Ecotoxicology and Environmental Safety·Shuting WangDayong Wang
Jun 3, 2021·Environmental Toxicology and Chemistry·Yimeng LiTianshu Wu
Dec 21, 2021·Advances in Nutrition·María-Carmen López de Las HazasAlberto Dávalos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.