PMID: 11903915Mar 21, 2002Paper

Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Fabrizio de PontiGianmario Frigo

Abstract

5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also be involved. Differences may exist between the small bowel and colon. Our aims were: (i) to compare the prokinetic effect exerted by the 5-HT4 receptor agonist ML10302 in the canine small bowel and colon in vivo; and (ii) to investigate the role of tachykininergic pathways in mediating this response. In fasting, conscious dogs, chronically fitted with electrodes and strain-gauge force transducers along the small bowel and colon, intravenous injection of ML10302 (35 microg kg-1) immediately stimulated spike activity and significantly increased propagated myoelectrical events at both intestinal levels. In the small bowel, the effects of ML10302 were unchanged by previous administration of the selective NK1 tachykinin receptor antagonist SR140333, the NK2 tachykinin receptor antagonist SR48968, or the NK3 tachykinin receptor antagonist SR142801. In the colon, all tachykinin receptor antagonists significantly inhibited stimulation of spike and mechanical activity by ML10302, without affecting ML10302-induced propagated myoelectrical e...Continue Reading

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Citations

Apr 21, 2016·Journal of Neurogastroenterology and Motility·Kumi NakayaShin Fukudo
Mar 24, 2004·British Journal of Pharmacology·Alessandro LecciCarlo Alberto Maggi
Apr 18, 2012·Respiration; International Review of Thoracic Diseases·Brian D MooreEdward S Schelegle
Oct 18, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paul P BertrandRebecca L Bertrand
Oct 16, 2020·Fundamental & Clinical Pharmacology·Artur UmerRoman P Korolkiewicz

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