Intestinal Mucin Induces More Endocytosis but Less Transcytosis of Nanoparticles across Enterocytes by Triggering Nanoclustering and Strengthening the Retrograde Pathway.

ACS Applied Materials & Interfaces
Dan YangQiang Zhang

Abstract

Mucus, which is secreted by the goblet cells of enterocytes, constitutes the first obstacle encountered for the intestinal absorption of nanomedicines. For decades, mucus has simply been regarded as a physical barrier that hinders the permeation and absorption of drugs, because of its high viscosity and reticular structure, whereas the interaction of mucus ingredients with nanomedicines is usually neglected. It is unclear whether glycoproteins, as the main components of mucus, interact with nanomedicines. We also do not know how the potential interaction affects the subsequent transportation of nanomedicines through the intestinal epithelium. In this study, mucin as the key element of mucus was investigated to characterize the interaction of nanomedicines with mucus. PEG-modified gold nanoparticles (PGNPs) were fabricated as model nanoparticles. Mucin was found to adhere to the nanoparticle surface to form a corona structure and induce the clustering of PGNPs by joining particles together, demonstrating the interaction between mucin and PGNPs. In addition, two intestinal epithelia, Caco-2 (non- mucus secretion) and HT-29 (high mucus secretion), were compared to evaluate the influence of mucin on the cellular interaction of PGNP...Continue Reading

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Citations

Jan 27, 2019·International Journal of Molecular Sciences·Miyu IshiiNoriaki Nagai
Jul 26, 2018·International Journal of Molecular Sciences·Noriaki NagaiNaohito Kawasaki
Feb 13, 2021·Drug Delivery and Translational Research·Irene SantalicesMaría José Alonso
Mar 2, 2021·International Journal of Pharmaceutics·Liu LiuXiaoqin Chu
Feb 23, 2021·Asian Journal of Pharmaceutical Sciences·Huan WangChangyou Zhan
Jul 31, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Wenjun WangHuiling Hu
May 5, 2021·The Science of the Total Environment·Xiaoquan Huang, Meng Tang
Jun 25, 2021·Advanced Drug Delivery Reviews·Matthias MarczynskiOliver Lieleg
Nov 18, 2021·ACS Applied Materials & Interfaces·Juan Gonzalez-ValdiviesoPilar Acedo

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