Sep 27, 2019

Intestinal organoids in infants and children

Pediatric Surgery International
Sinobol ChusilpAgostino Pierro

Abstract

Recent advances in culturing of intestinal stem cells and pluripotent stem cells have led to the development of intestinal organoids. These are self-organizing 3D structures, which recapitulate the characteristics and physiological features of in vivo intestinal epithelium. Intestinal organoids have allowed the development of novel in vitro models to study various gastrointestinal diseases expanding our understanding of the pathophysiology of diseases and leading to the development of innovative therapies. This article aims to summarize the current usage of intestinal organoids as a model of gastrointestinal diseases and the potential applications of intestinal organoids in infants and children. Intestinal organoids allow the study of intestinal epithelium responses to stress factors. Mimicking intestinal injury such as necrotizing enterocolitis, intestinal organoids increases the expression of pro-inflammatory cytokine genes and shows disruption of tight junctions after they are injured by lipopolysaccharide and hypoxia. In cystic fibrosis, intestinal organoids derived from rectal biopsies have provided benefits in genetic studies and development of novel therapeutic gene modulation. Transplantation of intestinal organoids via...Continue Reading

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Mentioned in this Paper

Study
In Vivo
Pluripotent Stem Cells
Genes
Drug Modulation Therapy
Cystic Fibrosis
Gastrointestinal Diseases
Transplantation
Biopsy of Rectum (Procedure)
Colonic Epithelium

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