Intestinal pathology during acute toxoplasmosis is IL-4 dependent and unrelated to parasite burden

Parasite Immunology
M B NickdelCraig W Roberts

Abstract

The role of interleukin-4 (IL-4) during the course of Toxoplasma gondii infection was studied using IL-4-/- mice and their wild-type (WT) counterparts on a C57BL/6 background. Following oral infection with T. gondii tissue cysts an exacerbative role for IL-4 was demonstrated and IL-4-/- mice were found to be more resistant to infection than WT mice as measured by significantly reduced mortality. Furthermore pathology in the small intestine was less severe in IL-4-/- mice although conversely liver pathology was greater than in wild-type mice. Significantly, plasma IL-12 and IFN-gamma levels, which peaked at days 6 and 8, respectively, were higher in IL-4-/- mice. The exacerbatory role of IL-4 in the intestine was found by competitive RT-PCR not to be associated with increased parasite burdens but was related to comparative expression of IL-10.

References

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Dec 22, 1999·Parasite Immunology·F RobertsR McLeod
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Feb 13, 2001·Infection and Immunity·M B NickdelC W Roberts
Mar 12, 2003·The Journal of Experimental Medicine·Lawrence L JohnsonStephen T Smiley

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Citations

Sep 8, 2012·Seminars in Immunopathology·Christopher D DupontChristopher A Hunter
Oct 7, 2011·PloS One·Marta G CavalcantiMarcelo T Bozza
Oct 23, 2013·PloS One·Bo HuangFangli Lu
May 30, 2009·Clinical & Developmental Immunology·Joanna Matowicka-KarnaHalina Kemona
Jun 2, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·C S ChouS C Lai
Jun 29, 2010·Trends in Parasitology·Fiona L HenriquezCraig W Roberts
Nov 30, 2007·Immunology Letters·Fiona M MenziesCraig W Roberts
Oct 18, 2006·Parasite Immunology·T Evering, L M Weiss
Sep 14, 2006·The Korean Journal of Parasitology·Ki-Nam KangYoung-Ha Lee
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catherine RonetDominique Buzoni-Gatel

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