PMID: 6776013Jun 1, 1980

Intestinal permeability and screening tests for coeliac disease

Gut
I CobdenA T Axon

Abstract

In disease states of the small intestine--for example, gluten-sensitive enteropathy--there is an increased permeability to large molecules. This increased permeability extends to polar molecules of intermediate size such as disaccharides, whereas small polar molecules are malabsorbed. A recently-developed oral test, based on the simultaneous administration of two test substances, cellobiose (a disaccharide) and mannitol (a small polar molecule) has been used to investigate permeability in a variety of gastrointestinal diseases, the result of the test being expressed as the ratio (cellobiose/mannitol) of the five hour urinary recoveries of the two probe molecules. Results for patients with pancreatic insufficiency, intestinal bacterial overgrowth, primary hypolactasia, ileocolic or colonic Crohn's disease, and ulcerative colitis were comparable with those in normal controls, whereas in 23 out of 24 untreated coeliacs, and five out of eight patients with Crohn's disease involving the more proximal small bowel, the cellobiose/mannitol ratio was clearly abnormal. A study of its application as a screening procedure for coeliac disease showed that the test was both sensitive and accurate, with fewer false-positive and false-negative ...Continue Reading

References

Feb 1, 1975·American Journal of Clinical Pathology·E L Krawitt, W L Beeken
May 24, 1975·Lancet·G MetzL M Blendis
May 1, 1978·The Journal of Pediatrics·J P ButsA Bonin
Jul 28, 1973·British Medical Journal·G E Sladen, P J Kumar
Oct 8, 1964·The New England Journal of Medicine·R M KIVELD LIEBOWITZ

Citations

Feb 1, 1988·European Journal of Pediatrics·J V PledgerE J Eastham
Apr 1, 1986·Diabetologia·A D MooradianR L Gebhard
Oct 1, 1993·Diseases of the Colon and Rectum·W A KoltunD J Schoetz
May 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·I CobdenA T Axon
Feb 27, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·A G Davidson, M A Bridges
Feb 28, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·C A NorthropR H Behrens
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·L T Weaver
Feb 20, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M SecondulfoV Esposito
Mar 28, 1981·Lancet·R Lossel
Mar 28, 1981·Lancet
Mar 14, 1981·Lancet
Jun 16, 1984·Lancet·G MinoliH Rainer
Jun 16, 1984·Lancet·M Lopez-BreaL Aragon
Jun 16, 1984·Lancet·C P O'MahonyC F Feighery
Feb 2, 1985·Lancet
Apr 12, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Edgardo SmecuolJulio César Bai
Jan 12, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M SecondulfoR Carratù
Apr 19, 2003·Journal of Gastroenterology and Hepatology·Ashkan FarhadiAli Keshavarzian
Oct 13, 2006·Current Opinion in Gastroenterology·Stefano Guandalini, Ranjana Gokhale
Aug 16, 2001·Nuclear Medicine Communications·G ArslanI S Yildirim
Aug 1, 1984·Biological Reviews of the Cambridge Philosophical Society·M L Gardner
Jan 1, 1996·APMIS. Supplementum·S U Friis
Apr 9, 2009·Veterinary Clinical Pathology·Stefanie KlennerThomas Spillmann
Sep 1, 1988·Archives of Disease in Childhood·K A NathavitharanaA S McNeish
Mar 1, 1989·Archives of Disease in Childhood·M S MurphyM F Laker
Jun 1, 1990·Archives of Disease in Childhood·A M DalzellD P Heaf
Jul 1, 1991·Archives of Disease in Childhood·L GrecoG Budillon
Jul 3, 1982·British Medical Journal·A D PearsonR Nelson
Jul 1, 1987·Journal of Clinical Pathology·L D JubyA T Axon
Jan 1, 1992·Intensive Care Medicine·C E HarrisR R Macmillan
Apr 21, 2004·European Journal of Gastroenterology & Hepatology·David J UnsworthRobert J Lock
Jan 25, 2008·European Journal of Pediatrics·Deanne L V GreenwoodJohn W Sentry
Mar 1, 1988·Scandinavian Journal of Gastroenterology·K J FotherbyG Neale
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·R M van ElburgH S Heymans
Feb 1, 1993·Scandinavian Journal of Gastroenterology·J SöderholmC Tagesson
Apr 1, 1990·Scandinavian Journal of Gastroenterology·G OlaisonC Tagesson
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·S M Riordan, T D Bolin
Oct 1, 1989·Scandinavian Journal of Gastroenterology·M AinsworthO B Schaffalitzky de Muckadell
Aug 25, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kim van WijckKaatje Lenaerts
Mar 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca MieleAntonio Grieco
Sep 17, 2013·Clinical and Experimental Pharmacology & Physiology·Ivana R SequeiraRoger D Hurst
Feb 1, 1990·Biochemical Medicine and Metabolic Biology·H S BabbarA Mahmood
Dec 1, 1982·European Journal of Clinical Investigation·M F LakerI S Menzies
May 1, 1995·Gastroenterology·I BjarnasonD Hollander
Jun 8, 2001·Seminars in Immunology·L ShaoL Mayer
Jul 26, 2016·Canadian Journal of Gastroenterology & Hepatology·Seema RajaniJustine M Turner
Jul 18, 2015·Nutrients·Natasha Tasevska
Jan 13, 2011·The American Journal of Gastroenterology·Jessica R BiesiekierskiPeter R Gibson
Jan 1, 1988·Medical & Biological Engineering & Computing·E J CroweP G Ross
Aug 26, 2009·World Journal of Gastroenterology : WJG·Firdevs TopalOzlem Yonem
Jun 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·N C WoodH M Prison

Related Concepts

Celiac Disease
Cellobiose
IIeocolitis
Intestinal Absorption
(L)-Mannitol

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