PMID: 8596232Apr 3, 1996Paper

Intestinal permeability, gastric intramucosal pH, and systemic endotoxemia in patients undergoing cardiopulmonary bypass

JAMA : the Journal of the American Medical Association
D W RiddingtonJ F Bion

Abstract

To examine the relationship between gastric intramucosal pH, intestinal permeability, endotoxemia, and oxygen delivery in patients undergoing cardiopulmonary bypass (CPB). Prospective, observational study. Tertiary care center. Fifty patients undergoing elective cardiac surgery and 10 patients awaiting elective cardiac surgery. Patients received chromium 51-labeled ethylenediaminetetraacetic acid (51Cr-EDTA) as a marker of intestinal permeability; insertion of a nasogastric tonometer to measure intramucosal pH (pHi); insertion of a pulmonary artery catheter to measure systemic oxygen delivery and consumption variables; arterial blood sampling for plasma endotoxin by the Limulus amebocyte lysate assay; and blood and urine sampling for measurement of 51Cr-EDTA. Systemic oxygen delivery, duration of gastric mucosal acidosis, absorption of 51Cr-EDTA, appearance of systemic endotoxemia, renal dysfunction, and duration of hospital stay. Median (range) 24-hour urinary recovery of 51Cr-EDTA in patients was 10.6% (2.1% to 40.2%) while that in controls was 1.2% (0.7% to 2.0%, P<.001). Intestinal permeability increased during CPB. The median (range) for the lowest pHi after bypass was 6.98 (6.74 to 7.17). The pHi did not decline until CPB...Continue Reading

Associated Clinical Trials

Citations

Oct 16, 2008·World Journal of Gastroenterology : WJG·Ying-Jie SunJin Zhou
Dec 18, 2008·PloS One·Joep P M DerikxWim A Buurman
Jan 22, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leonid G ErmilovCarlos B Mantilla
Nov 13, 2010·World Journal of Gastroenterology : WJG·Joep P M DerikxWim A Buurman
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Jan 22, 2013·Digestive Diseases and Sciences·Ying-Jie SunTie-Zheng Zhang
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