PMID: 2951220Jan 1, 1987Paper

Intestinal permeability in diabetic diarrhoea

Diabetic Medicine : a Journal of the British Diabetic Association
B T CooperR J Corrall


Small intestinal permeability to mannitol and lactulose was studied in 12 patients aged 36-70 (mean 56) years with diabetic diarrhoea (DD). Ten uncomplicated diabetics aged 24-56 (mean 37) years and 25 normal subjects aged 22-60 (mean 37) years served as controls. Permeability was assessed by measuring urinary recovery of the test substances after oral ingestion. Mean lactulose excretion in patients with DD was significantly lower than in normal controls but was not significantly different from the uncomplicated diabetics. Mean lactulose excretion was not significantly different in the three groups. However, lactulose to mannitol excretion ratios (LMER) were significantly higher in patients with DD compared to the controls or the uncomplicated diabetics. LMER in seven patients with DD were outside the normal range. LMER in patients with DD did not correlate with blood urea, small intestinal transit time, faecal fat excretion, small intestinal bacterial overgrowth, duration of diabetes or duration of diarrhoea. Jejunal morphology was normal in all patients with DD. It was concluded that small intestinal permeability was abnormal in some patients with DD and that this might be a factor in the aetiology of the diarrhoea.


Nov 25, 1978·British Medical Journal·A M Molloy, G H Tomkin
Sep 1, 1985·Age and Ageing·W M SaweirsT S Low-Beer
Feb 1, 1970·Annals of Internal Medicine·F GoldsteinO D Kowlessar
Mar 1, 1983·Annals of Internal Medicine·M Feldman, L R Schiller
Sep 1, 1984·Digestive Diseases and Sciences·S O Ukabam, B T Cooper
Dec 1, 1984·Journal of Clinical Gastroenterology·B T Cooper
Jan 1, 1965·The American Journal of Medicine·N MADANAGOPALANB ROWE


Feb 20, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M SecondulfoV Esposito
Jul 3, 1998·Gastroenterology Clinics of North America·N Unno, M P Fink
Jan 12, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M SecondulfoR Carratù
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Alessio Fasano, Terez Shea-Donohue
Jan 1, 1994·Gut·I Bjarnason
Jan 1, 1992·Intensive Care Medicine·C E HarrisR R Macmillan
Oct 30, 2004·Scandinavian Journal of Gastroenterology·I BjarnasonK Teahon
Jul 1, 1993·Mayo Clinic Proceedings·M A ValdovinosB R Zimmerman
Aug 15, 2008·Journal of Animal Physiology and Animal Nutrition·D C HernotPatrick G Nguyen
Jul 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·B F Clarke, R J Young
May 1, 1995·Gastroenterology·I BjarnasonD Hollander
Apr 6, 2016·Journal of Animal Physiology and Animal Nutrition·Mickaël P WeberPatrick G Nguyen
Aug 1, 2002·Oncogene·Rebecca B Scarr, Phillip A Sharp
Sep 19, 2003·American Journal of Veterinary Research·Mickaël P WeberHenri J Dumon
Sep 13, 2002·American Journal of Veterinary Research·Mickaël P WeberPatrick G Nguyen
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·C RübeM Eder
Mar 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·R CarratùF Prisco
Apr 13, 1999·The American Journal of Physiology·J B MeddingsD G Gall

Related Concepts

Breathalyzer Tests
Diabetes Mellitus
Complications of Diabetes Mellitus

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.