PMID: 3123634Jul 1, 1987

Intestinal permeability to [51Cr]EDTA in children with Crohn's disease and celiac disease

Journal of Pediatric Gastroenterology and Nutrition
D TurckG Fontaine

Abstract

[51Cr]EDTA was used as a probe molecule to assess intestinal permeability in 7 healthy control adults, 11 control children, 17 children with Crohn's disease, and 6 children with untreated celiac disease. After subjects fasted overnight, 75 kBq/kg (= 2 microCi/kg) 51Cr-labeled EDTA was given by mouth; 24-h urinary excretion of [51 Cr]EDTA was measured and expressed as a percentage of the total oral dose. Mean and SD were as follows: control adults 1.47 +/- 0.62, control children 1.59 +/- 0.55, and patients with Crohn's disease or celiac disease 5.35 +/- 1.94. The difference between control children and patients was statistically significant (p less than 0.001). These results show that intestinal permeability to [51Cr]EDTA is increased among children with active or inactive Crohn's disease affecting small bowel only or small bowel and colon, and with untreated celiac disease. The [51Cr]EDTA permeability test could facilitate the decision to perform more extensive investigations in children suspected of small bowel disease who have atypical or poor clinical and biological symptomatology.

Citations

Sep 1, 1993·Digestive Diseases and Sciences·M J ZuckermanH Ho
Feb 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·M Kuitunen, E Savilahti
Dec 24, 1988·BMJ : British Medical Journal·I BjarnasonA J Levi
Mar 7, 2008·World Journal of Gastroenterology : WJG·Jaya BenjaminYogendra K Joshi
Jun 3, 2011·World Journal of Gastroenterology : WJG·Vanya A GerovaDobrin A Svinarov
Jan 1, 1990·Journal of Internal Medicine. Supplement·K D CrissingerD N Granger
Jan 1, 1993·Scandinavian Journal of Gastroenterology·J Kjeldsen, O B Schaffalitzky de Muckadell
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·S M Riordan, T D Bolin
Oct 1, 1989·Scandinavian Journal of Gastroenterology·M AinsworthO B Schaffalitzky de Muckadell

Related Concepts

Celiac Disease
Chromium Radioisotopes
IIeocolitis
Edetic Acid, Sodium Salt
Intestines, Small
Permeability

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