PMID: 7543703Aug 1, 1995Paper

Intestinal reperfusion up-regulates inducible nitric oxide synthase activity within the lung

Surgery
R H TurnageS I Myers

Abstract

This study examines the hypothesis that pulmonary inducible nitric oxide synthase (iNOS) activity is up-regulated during intestinal reperfusion and that inhibition of NO generation exacerbates pulmonary microvascular dysfunction. Sprague-Dawley rats underwent intestinal ischemia and reperfusion (IIR) or sham operation (SHAM). Pulmonary iNOS activity was measured by quantitating the conversion of L-arginine (L-Arg) to L-citrulline. Another set of animals undergoing IIR or SHAM received an inhibitor of NOS (NG-nitro-L-arginine methylester; L-NAME; 20 mg/kg intravenously), substrate for NO generation (L-Arg; 300 mg/kg intravenously), or vehicle (normal saline solution; 3 ml). Pulmonary microvascular dysfunction was then quantitated by measuring the extravasation of Evans blue dye (EBD) into the lung. Inducible NOS activity was six times greater in the lungs of animals sustaining IIR when compared with SHAM (p = 0.0005). The concentration of EBD within the lungs of animals sustaining IIR was 30% greater than SHAM (p < 0.05). Inhibiting NOS with L-NAME significantly increased pulmonary EBD concentration of both IIR and SHAM groups when compared with normal saline solution-treated animals (p < 0.0001). Treatment with L-Arg prevented ...Continue Reading

Citations

Apr 17, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G CampanholleNiels Olsen Saraiva Camara
Feb 22, 2005·American Journal of Surgery·Faruk O AytekinAkin Ozden
Jul 2, 1999·Thrombosis Research·A Aydemir-KoksoyS Yavuzer
Mar 22, 2001·The British Journal of Surgery·C KöksoyI Gürhan
Oct 14, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey M Dodd-OHamid Rabb
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·F HinderD L Traber
Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·Le Feng WangSanjay Mehta
Jul 3, 2013·American Journal of Surgery·Atilla CelikAhu Kemik
Oct 24, 2007·The Journal of Surgical Research·Bahram RasoulianAli Khoshbaten
Nov 24, 2004·The Journal of Surgical Research·Kazuhisa ArakawaYasuo Morishita
Jan 5, 2005·Free Radical Biology & Medicine·Koji ItoSaburo Horikawa
May 29, 2003·The Journal of Thoracic and Cardiovascular Surgery·Alain SerrafClaude Planché
Jan 8, 1999·The Journal of Surgical Research·J L IglesiasR H Turnage
Jun 12, 2003·World Journal of Gastroenterology : WJG·Jun-Lin ZhouXin-Li Huang
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharon DaniliucLahat Nitza

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