Intestinal response to growth factors administered alone or in combination with human [Gly2]glucagon-like peptide 2

The American Journal of Physiology
D J DruckerPatricia L Brubaker

Abstract

The control of intestinal epithelial growth is regulated by interactions of growth factors in various cellular compartments of the small and large bowel. Little information is available on the intestinal growth response to combinations of growth factors. We studied the intestinotrophic properties of a dipeptidyl peptidase IV resistant glucagon-like peptide 2 (GLP-2) analog, human [Gly2]GLP-2 (h[Gly2]GLP-2), as well as of epidermal growth factor (EGF), long [Arg3]insulin-like growth factor I (LR3IGF-I), [Gly1]IGF-II, and human growth hormone (hGH), administered by subcutaneous injection alone or in combination in mice. At the doses tested, h[Gly2]GLP-2 was the most potent agent for increasing small and large bowel mass. Mice treated with h[Gly2]GLP-2 and either GH or IGF-I exhibited greater increases in histological parameters of small intestinal growth than did mice treated with h[Gly2]GLP-2 alone. Administration of all five growth factors together induced significant increases in crypt plus villus height and in small and large bowel length and weight. The results of these experiments define regional differences in both the cellular targets and relative activities of intestinotrophic molecules and raise the possibility that sel...Continue Reading

References

Jul 6, 1991·Lancet·P B SullivanN A Wright
Dec 1, 1991·The American Journal of Physiology·J A BarnardR J Coffey
Jan 1, 1982·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A I Al-Nafussi, N A Wright
Oct 1, 1982·Gut·H S BestermanS R Bloom
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·A WardC F Graham
Jul 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·T A ByrneD W Wilmore
Jan 1, 1996·Journal of Pediatric Surgery·F SwanikerE W Fonkalsrud
Apr 1, 1996·Scandinavian Journal of Gastroenterology·J H Park, J A Vanderhoof
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D J DruckerP L Brubaker

❮ Previous
Next ❯

Citations

Mar 11, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·P A KitchenA Forbes
Jun 19, 2001·Annals of Medicine·M C L'Heureux, P L Brubaker
Feb 14, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gary R MartinDavid L Sigalet
Jun 18, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Paul A KitchenJulian R F Walters
Mar 31, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·David L SigaletKeith A Sharkey
Apr 30, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Katherine J Rowland, Patricia L Brubaker
Mar 9, 2007·Neonatology·Susan BodéGorm Greisen
Oct 16, 2003·Physiological Genomics·Geneviève Aubin-HouzelsteinJean-Jacques Panthier
Jul 25, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sara BaldassanoJackie D Wood
May 1, 2021·Animals : an Open Access Journal From MDPI·William F MillerBradley J Johnson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.