Intestinal translocation of Streptococcus suis type 2 EF+ in pigs

Veterinary Microbiology
Bas SwildensT A Niewold

Abstract

Sepsis with subsequent multisystem organ failure after translocation of bacteria from the gut is a serious risk associated with stress situations. We showed that intestinal bacterial translocation could be one of the pathways for pathogenic Streptococcus suis infections in the pig. In 24 piglets weighing 10-14 kg, free of the extracellular factor (EF+) producing phenotype of S. suis serotype 2, a silicon canula was placed in the proximal jejunum to enable intestinal inoculation and bypassing the upper alimentary tract. The pigs were individually housed. After stress induction in 18 pigs by means of a truck drive in individual cages for 1h, pigs were inoculated through the intestinal canula either with S. suis type 2 EF+ or with growth medium only, and put back in their original housing. The six not transported pigs were also inoculated with the same strain. To prevent oral self-infection, faeces were collected in a bag that was glued around the anus. Clinical and behavioral symptoms were recorded for 72 h post inoculation, and then the animals were sacrificed for pathological and bacteriological examination. In three animals, the inoculation strain was re-isolated from mesenterial lymph nodes and typically affected organs. No S...Continue Reading

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Citations

Dec 24, 2013·Journal of Animal Science and Biotechnology·Juliana Abranches Soares AlmeidaJames Eugene Pettigrew
Mar 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nguyen Thi Hoang MaiConstance Schultsz
May 16, 2009·Enfermedades infecciosas y microbiología clínica·Carmen AspirozMaría José Aldea
Apr 3, 2007·Veterinary Immunology and Immunopathology·Stephen M WilsonMichael Bailey
Dec 20, 2014·The Journal of Infectious Diseases·Maria Laura FerrandoConstance Schultsz
Aug 28, 2014·Frontiers in Cellular and Infection Microbiology·Marcus FuldeRalph Goethe
Aug 12, 2016·Pathogens·Franziska WarneboldtChristoph Georg Baums
Aug 19, 2007·Animal Health Research Reviews·Marcelo GottschalkJiangu Xu
Nov 23, 2007·Critical Reviews in Microbiology·Michael Greger
Feb 7, 2008·Epidemiology and Infection·E MaUNKNOWN Collaborative Study Group on Streptococcus suis infection in Hong Kong
Sep 21, 2011·Antimicrobial Agents and Chemotherapy·Jose Antonio EscuderoBruno Gonzalez-Zorn
Dec 8, 2009·Emerging Infectious Diseases·Nahuel FittipaldiMarcelo Gottschalk
Dec 17, 2011·Emerging Infectious Diseases·Nahuel FittipaldiMarcelo Gottschalk
May 19, 2006·Emerging Infectious Diseases·Hongjie YuUNKNOWN Streptococcus suis study groups
Mar 5, 2014·Transboundary and Emerging Diseases·K ManeeratP Srimanote
Mar 19, 2014·Applied and Environmental Microbiology·Laetitia BonifaitCaroline Duchaine
Oct 28, 2015·PLoS Neglected Tropical Diseases·Anusha van SamkarDiederik van de Beek
Mar 22, 2016·PloS One·Edoardo ZaccariaPeter van Baarlen
Sep 3, 2020·Journal of Animal Science·Yijie HeYanhong Liu
Mar 1, 2021·Journal of Animal Science·Nienke de GrootGuillermo Ramis

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