Intestinal transport of cystine and cysteine in man: evidence for separate mechanisms

The Journal of Clinical Investigation
L E ROSENBERGS Segal

Abstract

Cystine and cysteine are transported by energy-dependent, mediated processes in human gut. When either of these amino acids is transported, only cysteine is recovered intracellularly, indicating that cystine is reduced to cysteine after achieving an intracellular location. In contrast to results with cystine, cysteine uptake is not defective in gut from cystinuric patients, nor do lysine and arginine compete with cysteine for transport. It is, therefore, concluded that cystine and cysteine are transported by different mechanisms, and that only the cystine transport mechanism is defective in cystinuria.

References

Dec 2, 1965·The New England Journal of Medicine·L E RosenbergJ M Holland
Mar 1, 1966·The Journal of Clinical Investigation·L E RosenbergS Segal
May 26, 1966·Biochimica Et Biophysica Acta·J C Crawhall, S Segal
Mar 12, 1964·The New England Journal of Medicine·M FOXS SEGAL
Aug 1, 1964·The Journal of Clinical Investigation·C F MCCARTHYM P TYOR
Mar 1, 1965·The Journal of Clinical Investigation·S O THIERL E ROSENBERG

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Citations

Jan 10, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·B States, S Segal
Oct 1, 1975·The Journal of Pediatrics·B StatesS Segal
Jun 27, 1968·The New England Journal of Medicine·L E RosenbergL J Elsas
Jan 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·S Segal, J C Crawhall
Jul 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·S Segal, I Smith
Jun 1, 1993·Australian and New Zealand Journal of Medicine·T J Furlong, D Stiel
Sep 1, 1979·Journal of Neurochemistry·S Segal, S M Hwang
Sep 1, 1971·The Journal of Clinical Investigation·C L MorinA Sass-Kortsak
May 25, 2004·The Journal of Physiology·Mital H DaveFrancois Verrey
Dec 1, 1982·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P P KamounC Ricour
Jun 21, 2016·Journal of Pharmaceutical Sciences·Teruo Murakami
Dec 1, 1979·Journal of Neurochemistry·S M Hwang, S Segal
Aug 1, 1980·Journal of Neurochemistry·S M HwangS Segal
Nov 1, 1982·Bioscience Reports·B OzegovićS Segal
Apr 1, 1978·The Journal of Urology·R J CaldwellM J Smith
May 22, 2007·The Journal of Nutrition·George K Grimble
Jan 24, 2007·The Journal of Nutrition·Ryan N DilgerDavid H Baker
Sep 20, 2002·Journal of the American Society of Nephrology : JASN·Luca Dello StrologoGianfranco Rizzoni
Jun 20, 1986·Journal of Chromatography·Z DeylM Horakova
Sep 3, 1984·Biochimica Et Biophysica Acta·S Bannai

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