PMID: 9419349Feb 21, 1998Paper

Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells

Proceedings of the National Academy of Sciences of the United States of America
M KanaiDaniel K Podolsky

Abstract

Intestinal trefoil factor (ITF), a small, compact protease-resistant peptide, is abundantly expressed in goblet cells of large and small intestine. Although several biological activities of ITF have been identified, including promotion of wound healing, stimulation of epithelial cell migration, and protection of intestinal epithelial barrier, little is known about signaling events through which ITF mediates its physiological function. In this study, the effects of exogenous ITF on mitogen-activated protein kinase (MAPK) signaling cascades were examined in IEC-6 cells, a nontransformed intestinal epithelial cell line that does not express endogenous trefoil peptides. Stimulation with ITF resulted in rapid decrease in extracellular signal-related protein kinase (ERK) activity and concomitant reduced ERK tyrosine phosphorylation. ITF also decreased activation of ERK activity induced by either transforming growth factor-alpha, which links extracellular stimuli to the Ras/Raf/MEK/ERK pathway via the epidermal growth factor receptor, or phorbol 12-myristate 13-acetate, which activates Raf through protein kinase C. ITF-induced inhibition of ERK activity was blocked by an inhibitor of tyrosine and dual-specific phosphatases, sodium ort...Continue Reading

References

Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·N A WrightC Pike
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S SuemoriD K Podolsky
Mar 1, 1995·Trends in Biochemical Sciences·E Cano, L C Mahadevan
Apr 1, 1994·Current Opinion in Cell Biology·G L Johnson, R R Vaillancourt
Jul 1, 1994·The Journal of Clinical Investigation·A DignassD K Podolsky
Nov 1, 1993·Gastroenterology·V Gülberg, A L Gerbes
Apr 26, 1996·The Journal of Biological Chemistry·K A Heidenreich, J L Kummer
Mar 1, 1996·Baillière's Clinical Gastroenterology·R Poulsom
Jan 1, 1996·Annual Review of Physiology·B E Sands, D K Podolsky

❮ Previous
Next ❯

Citations

Jul 16, 2008·Inflammatory Bowel Diseases·Michael A McGuckinGraham Radford-Smith
Jul 12, 2011·Inflammatory Bowel Diseases·Serena CatarziTeresa Iantomasi
Aug 5, 2000·Biochemical and Biophysical Research Communications·Y H ChenX D Tan
Apr 23, 2011·Histochemistry and Cell Biology·Adnana N Paunel-GörgülüNicole Dünker
Mar 8, 2007·Digestive Diseases and Sciences·Stine KjellevSteen S Poulsen
Jun 26, 1999·The British Journal of Surgery·R J LongmanR Poulsom
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yasuhiko KimuraM Eric Gershwin
Oct 7, 2006·Current Opinion in Gastroenterology·L M Lichtenberger
May 14, 1999·Gut·W M WongN A Wright
Dec 14, 2006·The American Journal of Chinese Medicine·Xi-Ping LiRong Hu
Mar 22, 2003·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·C Chris Yun
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·A WiedeW Hoffmann
Nov 6, 2001·American Journal of Respiratory Cell and Molecular Biology·S R White
Jun 5, 2004·Peptides·Shahin EmamiChristian Gespach
Jun 27, 2007·The American Journal of Pathology·Chang TongWancai Yang
Dec 28, 1999·Gastroenterology·C TomasettoM C Rio
Dec 8, 2004·The American Journal of Pathology·Isao NozakiAnthony J Demetris
Jul 11, 2006·Cell Transplantation·A J DemetrisAmadeo Marcos
Sep 11, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terence ChiuEnrique Rozengurt
Aug 2, 2003·Journal of Cellular Physiology·Osvaldo ReyEnrique Rozengurt
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Terence ChiuEnrique Rozengurt
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S EmamiC Gespach
Mar 14, 2001·American Journal of Physiology. Cell Physiology·T Chiu, E Rozengurt
Mar 7, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terence ChiuEnrique Rozengurt
Jun 15, 2006·World Journal of Gastroenterology : WJG·A-J DemetrisIsao Nozaki
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·D Iwakiri, D K Podolsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.