Intestinal-type carcinoma of gallbladder. A histochemical and immunologic study.

Cancer
M Laitio, I P Häkkinen

Abstract

Two intestinal carcinomas of the gallbladder are presented. In both carcinomas the structure was papillary in superficial parts; the deeper ones also tended to an adenomatous structure. One of the tumors was bordered by a mucosa, with both intestinal- and antral-type metaplastic islands. The tumor was mainly a typical papilloma with malignant degeneration and infiltrative growth. The intestinal structure was morphologically clear in the papillary area of both carcinomas, but not distinct in the invasive part of the tumor. In both tumors, goblet cells and columnar cells with a distinct brush border were noted. Histochemical and immunologic methods were used in the identification of the glycoproteins of the tumor cells. With both methods the intestinal character of the tumor could be shown. A positive fluorescence was achieved with an intestinal antiserum in well-differentiated tumorous areas containing goblet cells, as well as in the intestinal metaplastic areas. In the same areas the gallbladder-specific antigen was negative. The antiserum isolated from the normal gastric mucosa and corresponding to neutral glycoprotein gave a positive fluorescence only in the nontumorous metaplastic gastric superficial-type epithelium and in t...Continue Reading

References

Jan 1, 1974·International Archives of Allergy and Applied Immunology·I P Häkkinen
Sep 15, 1968·International Journal of Cancer. Journal International Du Cancer·I HäkkinenJ Grönroos
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Mar 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S S SPICER

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Citations

Mar 1, 1995·Pathology International·K NishiharaM Tsuneyoshi
Aug 1, 1983·Pathology, Research and Practice·M Laitio
Dec 1, 1980·Pathology, Research and Practice·M Laitio, T Terho
Jan 1, 1983·Environmental Mutagenesis·P E Hartman
May 16, 2003·Pathology, Research and Practice·Daniela CabibiFederico Aragona
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M A MooreN Ito
May 1, 1982·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·O H Järvi, S Marin

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