Intestinal UDP-glucuronosyltransferase activities in rat and rabbit

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
M Vargas, M R Franklin

Abstract

1. Tissues other than the liver can contribute significantly to the drug-metabolizing capacity of an animal. In the current study, the glucuronidation of several aglycones in microsomes from the small intestinal mucosa of rat and rabbit has been investigated and compared with glucuronidation in liver microsomes. 2. UDP-glucuronosyltransferase activities in intestinal microsomes were generally higher in rabbit when compared with rat, ranging from 200 to 300% for 1-naphthol, 2-naphthol, 4-methylumbelliferone, 2-hydroxybiphenyl and 4-hydroxybiphenyl. 3. In contrast, hepatic activities were much higher in rat than in rabbit, ranging from 300 to 400% for 1-naphthol, 2-naphthol, 4-methylumbelliferone, 2-hydroxybiphenyl and testosterone; and from 150 to 250% for 4-nitrophenol and diclofenac. 4. In rabbit, activities in the small intestinal mucosa were comparable (70-100%) with hepatic activities for most aglycones. In rat, intestinal mucosa activities were much lower than in liver, with activities toward 1-naphthol, 2-naphthol, 4-nitrophenol, 4-methylumbelliferone, 2-hydroxybiphenyl and 4-hydroxybiphenyl in the small intestine representing 5-15% of hepatic activities. 5. With a higher intestine:liver activity ratio, intestinal UDP-glu...Continue Reading

References

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Citations

Apr 15, 2000·Journal of Pharmaceutical and Biomedical Analysis·R NarayananD A Williams
Apr 26, 2007·Critical Reviews in Food Science and Nutrition·K Nemeth, M K Piskula
Jun 23, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kristini K MilesJoseph K Ritter
Jan 23, 2010·Chemical Research in Toxicology·Yu-Qi HeZheng-Tao Wang

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