Intima-media thickness and arterial function in obese and non-obese children

BMC Obesity
Heidi WeberrußRenate Oberhoffer

Abstract

Obesity is an independent cardiovascular risk factor that contributes to the development of atherosclerosis. Subclinical forms of the disease can be assessed via sonographic measurement of carotid intima-media thickness (cIMT) and distensibility - both may already be altered in childhood. As childhood obesity increases to an alarming extent, this study compares vascular data of obese with normal weight boys and girls to investigate the influence of obesity on cIMT and distensibility of the carotid arteries. cIMT and distensibility of 46 obese children (27 girls) aged 7-17 years were compared with measures of 46 sex- and age-matched normal weight controls. cIMT and distensibility were measured by B- and M-mode ultrasound and expressed as standard deviation scores (SDS). Arterial distensibility was defined by arterial compliance (AC), elastic modulus (Ep), stiffness index β (β), and local pulse wave velocity β (PWV β). Obese girls had significantly stiffer arteries compared with normal weight girls (Ep SDS 0.64 ± 1.24 vs. 0 ± 1.06, β SDS 0.6 ± 1.17 vs. -0.01 ± 1.06 p < .01, PWV β 0.54 ± 1.2 vs. -0.12 ± 1.05 p < .05). No significant differences were observed for boys. In multiregression analysis, BMI significantly influenced Ep, β...Continue Reading

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Citations

Nov 24, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Annayya R AroorJames R Sowers
Dec 13, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiroshi FujiwaraKengo Yoshii
Jun 28, 2019·Childhood Obesity·Hafize Emine SönmezSalim Çalışkan
Apr 2, 2021·International Journal of Clinical Practice·Esra YazarlıBülent Alioğlu
May 31, 2021·Heart Failure Clinics·Efstratios KoutroumpakisAnita Deswal

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