Intima media thickness in children undergoing dialysis.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Luis Antonio ChavarriaElvia García-López

Abstract

Uremic vasculopathy, including vascular calcification, increases the risk for cardiovascular disease and mortality in chronic kidney disease (CKD) patients. We have investigated the prevalence and factors associated with vasculopathy in children undergoing peritoneal dialysis (PD) or hemodialysis (HD) in a single center. Common carotid intima media thickness (cIMT) and its relation with demographics, biochemical parameters and medication was analyzed in 60 patients (mean age 12.9 ± 3.4 years; 27 girls) treated with PD (n = 31) or HD (n = 29) for 34 ± 34 months. Patients were divided into two groups: normal cIMT and increased cIMT. Mean levels of calcium, phosphate and calcium/phosphate product were in the normal range, the but parathyroid hormone level, 729 ± 670 pg/mL, was higher than the National Kidney Foundation Kidney Disease Outcome Quality Iniative (K/DOQI) recommendations. Twenty-nine patients had increased cIMT, which was associated with time on dialysis of >2 years, hypercalcemia, higher daily dose of calcitriol and HD (vs. PD). In the multivariate analysis, accounting for time on dialysis, HD persisted as a risk for increased cIMT. The prevalence of increased cIMT in children on dialysis is similar to that reported i...Continue Reading

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Citations

Jun 5, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rukshana Shroff
Nov 20, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rukshana Shroff
Oct 1, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Juan Antonio Garcia-BelloNiels H Wacher
Apr 11, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bradley A WaradyFranz Schaefer
Aug 5, 2017·Journal of Korean Medical Science·Seung Seok HanDong Ki Kim
Nov 2, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Uwe Querfeld, Franz Schaefer
Sep 5, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaJulien Hogan

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