Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study

Metabolism: Clinical and Experimental
Akira SekikawaLewis H Kuller

Abstract

In men in the post-World War II birth cohort, that is, men aged 40 to 49 years, whites in the United States had significantly higher levels of intima-media thickness of the carotid arteries (IMT) than the Japanese in Japan (Electron-Beam Tomography and Risk Assessment Among Japanese and US Men in the Post World War II Birth Cohort [ERA JUMP] study). The difference remained after adjusting for traditional risk factors. Primary genetic effects are unlikely, given the degree to which IMT is increased in the Japanese who migrated to the United States. We investigated whether the differences in the distributions of lipoprotein subclasses explain the difference in IMT between the 2 populations. We examined population-based samples of 466 randomly selected men aged 40 to 49 years (215 whites from Allegheny County, Pennsylvania, and 241 Japanese from Kusatsu, Shiga, Japan). Lipoprotein subclasses were determined by nuclear magnetic resonance (NMR) spectroscopy. The whites had significantly higher levels of large very low-density lipoprotein particles and significantly lower levels of large high-density lipoprotein particles than the Japanese, whereas the 2 populations had similar levels of small low-density lipoprotein particles. The 2...Continue Reading

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Citations

Apr 2, 2010·The American Journal of Clinical Nutrition·Jina ChooUNKNOWN ERA-JUMP Study Group
Jul 5, 2013·Journal of Human Hypertension·A VishnuUNKNOWN ERA JUMP Study Group
Dec 3, 2016·Journal of Atherosclerosis and Thrombosis·Maryam ZaidKatsuyuki Miura
Mar 13, 2014·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Tomonori OkamuraHirotsugu Ueshima

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