Intimal cushions and endothelial nuclear elongation around mouse aortic branches and their spatial correspondence with patterns of lipid deposition.

American Journal of Physiology. Heart and Circulatory Physiology
Andrew R BondP D Weinberg

Abstract

Spatial variation in hemodynamic stresses acting on the arterial wall may explain the nonuniform distribution of atherosclerosis. In thoracic aortas of LDL receptor/apolipoprotein E double knockout mice, lesions develop preferentially around the entire circumference of intercostal branch ostia, regardless of age, with the highest prevalence occurring upstream. Additional chevron-shaped lesions occur further upstream of the ostia. This pattern differs from the age-related ones occurring in people and rabbits. In the present study, patterns of near-wall blood flow around intercostal ostia in wild-type mice were estimated from the morphology of endothelial nuclei, which were shown in vitro to elongate in response to elevated shear stress and to align with the flow, and wall structure was assessed from confocal and scanning electron microscopy. A triangular intimal cushion surrounded the upstream part of most ostia. Nuclear length-to-width ratios were lowest over this cushion and highest at the sides of branches, regardless of age. Nuclear orientations were consistent with flow diverging around the branch. The pattern of nuclear morphology differed from the age-related ones observed in rabbits. The intimal cushion and the distribut...Continue Reading

References

May 1, 1991·Journal of Biomechanical Engineering·G HelmlingerR M Nerem
Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D W KimB L Langille
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M J LevesqueR M Nerem
Nov 1, 1985·Journal of Biomechanical Engineering·M J Levesque, R M Nerem
Jul 1, 1984·Microvascular Research·S G EskinL T Navarro
Aug 1, 1981·Journal of Biomechanical Engineering·C F DeweyP F Davies
Mar 4, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·S E Barnes, P D Weinberg
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·S E Barnes, P D Weinberg
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·L HajraM I Cybulsky
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C J HartleyY X Wang
Jul 14, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C J McGillicuddyP D Weinberg
Oct 16, 2001·Experimental and Molecular Pathology·S E Barnes, P D Weinberg
Sep 1, 1961·The Journal of Physiology·J FOURMAN, D B MOFFAT
May 23, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Joan M GreveCharles A Taylor
Sep 22, 2006·Antioxidants & Redox Signaling·Hanjoong JoAmy Mowbray
Oct 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Akiva FeintuchC Ross Ethier
Oct 19, 2006·Journal of Biomechanics·Peter D Weinberg, C Ross Ethier
Jun 6, 2008·Journal of Biomechanical Engineering·Philippe SucoskyAjit P Yoganathan

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Citations

Jul 31, 2012·Mutagenesis·Gholamreza FazeliNicole Schupp
Jan 6, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew R BondPeter D Weinberg
Mar 2, 2019·The Journal of Experimental Medicine·Torben MentrupBernd Schröder
May 5, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Alois LametschwandtnerBernd Minnich

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