Intimal fibromuscular hyperplasia at the venous anastomosis of PTFE grafts in hemodialysis patients. Clinical, immunocytochemical, light and electron microscopic assessment

S H SwedbergS C Nicholls


Failure of arteriovenous communications used for chronic hemodialysis was studied during sequential 5-year periods after placement of either endogenous Brescia-Cimino (B-C) fistulas (50 patients) or polytetrafluoroethylene (PTFE, Gore-Tex) grafts (66 patients). Venous stenosis near the anastomosis was the reason for failure in 45% of PTFE grafts compared with 16% of B-C fistulas (p less than 0.001). Failure occurred, on average, 16 months after PTFE graft placement compared with 22 for B-C fistulas (p = NS). Proximal vein segments removed from five failed and two functioning PTFE graft communications were studied using light and electron microscopy and immunocytochemical techniques. All venous segments removed during surgical shunt repair exhibited a marked intimal hyperplasia. The intimal cellular component was almost exclusively smooth muscle. Accumulation of intracellular lipid droplets was not seen. Foam cells as well as extracellular lipid deposits were absent; macrophages and lymphocytes were absent from the zone of proliferation. Ultrastructural examination revealed a large proportion of extracellular matrix surrounding smooth muscle cells in the neointima. Collagen and elastin were present in the extracellular matrix, i...Continue Reading


Apr 1, 1979·Archives of Surgery·J L GiacchinoV K Bansal
Nov 1, 1979·Kidney International·S G RostandT E Andreoli
Jul 1, 1978·Archives of Internal Medicine·P A MennesH R Harter
Aug 12, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Feb 1, 1975·Archives of Surgery·W E Stehbens, A M Karmody
May 1, 1986·Progress in Cardiovascular Diseases·B G BrownH T Dodge
Jan 1, 1985·Annals of the New York Academy of Sciences·H R Baumgartner, K S Sakariassen
Apr 1, 1985·Experimental and Molecular Pathology·G R Campbell, J H Campbell
Mar 1, 1985·The Journal of Cell Biology·A M GownP L Lu
Aug 1, 1985·Annals of Surgery·S B PalderN L Tilney
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R RossL Harker
Oct 1, 1965·Histochemie. Histochemistry. Histochimie·J E Scott, J Dorling
Aug 1, 1974·Experimental Cell Research·N Kohler, A Lipton
Mar 28, 1974·The New England Journal of Medicine·A LindnerB H Scribner
Jan 5, 1967·The New England Journal of Medicine·D S FredricksonR S Lees
Mar 1, 1968·The British Journal of Surgery·R W Glashan, F Walker
Oct 1, 1969·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·R H SmalleyW R Blakeley
Nov 17, 1966·The New England Journal of Medicine·M J BresciaB J Hurwich
Oct 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M Hsu, E Soban
Apr 1, 1982·Radiology·S GlanzR Adamsons
May 1, 1981·Kidney International·M K ChanJ F Moorhead
Jul 1, 1980·The British Journal of Surgery·P J GuillouR C Kester
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT

❮ Previous
Next ❯


Oct 27, 2004·European Radiology·Renan UflackerUNKNOWN Investigators of the Clinical Trial Sponsored by Microvena Corporation
Jan 12, 2010·International Urology and Nephrology·Linda ShavitItzchak Slotki
Nov 5, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Robert B van TongerenCornelis M Bruijninckx
Aug 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Burnett S KellyPrabir Roy-Chaudhury
Sep 10, 2003·Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing·Kathleen A Gross
Jul 13, 1999·Journal of the American College of Surgeons·C J LeSarM R Smith
Sep 17, 2003·Cardiovascular Radiation Medicine·Jennifer BartonRobert Grove
Oct 24, 2000·The British Journal of Surgery·G J MurphyM L Nicholson
Oct 10, 1998·Kidney International·R Hakim, J Himmelfarb
Dec 9, 1998·Kidney International·N R NeyraR M Hakim
May 31, 2001·Kidney International·P Roy-ChaudhuryS C Heffelfinger
May 31, 2001·Kidney International·S L Goldstein, A Allsteadt
Nov 13, 2002·Kidney International·Burnett S KellyPrabir Roy-Chaudhury
May 20, 2003·Seminars in Dialysis·Liam F Casserly, Laura M Dember
Mar 11, 2004·Seminars in Vascular Surgery·Christopher J AbularrageSubodh Arora
Sep 16, 2003·Ultrasound Quarterly·M E Lockhart, M L Robbin
Dec 14, 1999·Current Opinion in Nephrology and Hypertension·J Himmelfarb
Jan 12, 2000·Current Opinion in Nephrology and Hypertension·J H Smits, P J Blankestijn
Dec 20, 2007·Current Opinion in Nephrology and Hypertension·Prabir Roy-Chaudhury, Timmy C Lee
Aug 9, 2006·Seminars in Dialysis·Devasmita Choudhury
Jun 21, 2011·Seminars in Dialysis·Paolo CravediPiero Ruggenenti
Jan 27, 2012·Seminars in Dialysis·Syed Ahmed, Prabir Roy-Chaudhury
May 12, 2010·International Journal of Clinical Practice·C I ColemanK M Reinhart
Mar 1, 2006·Journal of Biomechanical Engineering·Sunil UnnikrishnanAndreas S Anayiotos
Jan 25, 2008·Theoretical Biology & Medical Modelling·Paula Budu-GrajdeanuBrad H Rovin
Mar 13, 1998·Journal of Endovascular Surgery : the Official Journal of the International Society for Endovascular Surgery·E M MasudaC B Kamida
Feb 8, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Micah R ChanAlexander S Yevzlin
Mar 29, 2003·Radiology·Michael J WallaceKenneth C Wright
Jan 21, 2006·Radiology·Rebecca D LevitScott O Trerotola
Mar 18, 2008·World Journal of Surgery·George TsoulfasTatsuo Kawai
Jun 2, 2012·Expert Review of Cardiovascular Therapy·Michael J CollinsAlan Dardik
Apr 1, 1994·Annals of Medicine·S T Nikkari, A W Clowes
Nov 5, 2011·The American Journal of the Medical Sciences·Teng-Yao YangYu-Shien Ko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.