INtimal hyPerplasia evAluated by oCT in de novo COROnary lesions treated by drug-eluting balloon and bare-metal stent (IN-PACT CORO): study protocol for a randomized controlled trial.

Trials
Francesco BurzottaFilippo Crea

Abstract

Neointimal hyperplasia plays a pivotal role in the pathogenesis of in-stent restenosis in patients undergoing percutaneous coronary interventions. Drug-eluting balloons are a promising tool to prevent restenosis after coronary angioplasty. Moreover, an increased knowledge of the pathophysiology of restenosis my help improve therapeutic strategies. We present the design of an open-label, randomized three-arm clinical trial aimed to assess whether a strategy of bare-metal stent implantation with additional use of drug-eluting balloons, either before (pre-dilation) or after stenting (post-dilation), reduces the primary endpoint of in-stent neointimal hyperplasia area as compared with a strategy of bare-metal stent implantation alone. This primary endpoint will be assessed by optical coherence tomography at follow-up. Secondary endpoints will be the percentage of uncovered struts, and the percentage of struts with incomplete apposition. An ancillary study investigating the relation between systemic levels of endothelial progenitors cells and neointimal hyperplasia, and the interaction between endothelial progenitors cell levels and drug-eluting balloons has been planned. Thirty consecutive patients undergoing percutaneous coronary ...Continue Reading

References

Nov 15, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jacob GeorgeGad Keren
Aug 3, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·John Waugh, Antona J Wagstaff
Jul 4, 2006·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Nov 15, 2006·The New England Journal of Medicine·Bruno SchellerUlrich Speck
Jun 10, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Bruno SchellerUlrich Speck
Jul 26, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Giulio Guagliumi, Vasile Sirbu
Nov 1, 2007·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Francesco PratiMario Albertucci
Dec 25, 2009·Circulation. Cardiovascular Interventions·Ron Waksman, Rajbabu Pakala
Oct 12, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Juan Luis Gutiérrez-ChicoPatrick W Serruys

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Citations

Oct 24, 2012·Annals of Biomedical Engineering·Stefano Morlacchi, Francesco Migliavacca
Dec 4, 2014·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Giovanni Luigi De MariaFilippo Crea
Dec 12, 2017·Biomedical Materials·Meenasree BukkaMukty Sinha

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Methods Mentioned

BETA
coronary artery bypass
percutaneous transluminal coronary angioplasty
imaging techniques
pullback
ISA

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