PMID: 11336837May 5, 2001Paper

Intimin and the host cell--is it bound to end in Tir(s)?

Trends in Microbiology
G FrankelS Matthews

Abstract

Intimate bacterial adhesion to the intestinal epithelium is a pathogenic mechanism shared by several human and animal enteric pathogens, including enteropathogenic and enterohaemorrhagic Escherichia coli. Two bacterial protein partners involved in this intimate association have been identified, intimin and Tir. Some key remaining questions include whether intimin specifically interacts with one or more host-cell-encoded molecules and whether these contacts are a prerequisite for the subsequent intimate intimin-Tir association. Recent data support the hypothesis that the formation of a stable intimin-Tir relationship is the consequence of intimin protein interactions involving both host and bacterial components.

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Citations

Apr 4, 2006·Nature Reviews. Microbiology·Richard D HaywardKenneth G Campellone
Mar 14, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jack C LeoDirk Linke
Oct 16, 2007·Clinical Microbiology Reviews·Bryan CoburnB Brett Finlay
Mar 26, 2003·Infection and Immunity·Bianca C NevesStuart Knutton
Apr 5, 2005·Journal of Bacteriology·Valérie F CrepinGad Frankel
Apr 6, 2006·Journal of Bacteriology·Oliver MarchèsGad Frankel
Jul 10, 2004·Journal of Clinical Microbiology·Sarah A KühneKevin C Gough
Nov 8, 2005·Journal of Clinical Microbiology·Junkal GarmendiaGad Frankel
Dec 14, 2004·Microbiology and Molecular Biology Reviews : MMBR·Ian R HendersonDlawer Ala'Aldeen
Sep 6, 2008·Canadian Journal of Microbiology·Rubén Oliver-GonzalezFernando Navarro-Garcia
Oct 5, 2010·Gastroentérologie Clinique Et Biologique·E Im, C Pothoulakis
Jul 22, 2014·ACS Synthetic Biology·Carlos Piñero-LambeaLuis Ángel Fernández
Nov 29, 2005·Cellular Microbiology·Rosanna MundySiouxsie Wiles
Jan 13, 2006·Current Opinion in Microbiology·Emmanuelle CaronGad Frankel
Apr 12, 2003·Microbiology and Immunology·Keiji NaganoHiroshi Mori
Aug 27, 2009·Alimentary Pharmacology & Therapeutics·C Pothoulakis

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