Into the Unknown: A Chemical Biology Approach Provides Mechanistic Insight into HCV Entry.

Cell Chemical Biology
Fang ChenMansun Law

Abstract

In this issue of Cell Chemical Biology, Hu et al. (2020) demonstrate that chlorcyclizine blocks HCV fusion by targeting the putative fusion peptide on the viral envelope glycoprotein E1. The study provides new insights into the viral fusion machinery, presenting an opportunity to study novel antivirals against HCV.

References

Jan 18, 2015·Progress in Molecular Biology and Translational Science·Florian DouamFrançois-Loïc Cosset
Jul 5, 2018·Frontiers in Immunology·Yimin TongJin Zhong
Aug 21, 2019·Cold Spring Harbor Perspectives in Medicine·Gisa GeroldThomas Pietschmann

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