PMID: 11069569Nov 9, 2000Paper

Intolerance to hydrolysed cow's milk proteins in infants: clinical characteristics and dietary treatment

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A CarroccioG Iacono

Abstract

Multiple food intolerance in infants, including intolerance to extensively hydrolysed proteins (HP), is often difficult to treat. However, few data have been reported on clinical outcome and dietary treatment of these patients. To evaluate the clinical characteristics of patients with HP-intolerance and the long-term outcome of treatment with ass' milk. This study included 21 HP-intolerant infants (15 males, median age at diagnosis 2 months) treated with an ass' milk-based diet and 70 cow's milk (CM) intolerant infants (40 males, median age at diagnosis 3 months) treated with casein hydrolysate milk-based diet. All patients were followed-up for a median period of 4 years. Both HP-intolerance and intolerance to other foods were diagnosed according to the double-blind placebo-controlled procedure. Formal CM-challenges were conducted at yearly intervals until tolerance was demonstrated. At diagnosis and after one year of the respective diets, the following growth parameters were determined: relative weight for sex and age, relative weight for height and height z-score. During the study period, multiple food intolerance was documented in 21/21 HP-intolerant infants (ass' milk group) and in 20/70 infants with CM-intolerance but tole...Continue Reading

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