PMID: 3104948Jan 1, 1987

Intoxicating effects of lorazepam and barbital in rat lines selected for differential sensitivity to ethanol

Psychopharmacology
K HellevuoC Kim

Abstract

The motor impairing effects and plasma concentrations of barbital and lorazepam were studied in the alcohol tolerant (AT) and alcohol non-tolerant (ANT) rat lines developed for low and high sensitivity to motor impairment from ethanol. The mixed (M) line, from which the AT and ANT rats were derived, was also included in the study. Like ethanol, barbital and lorazepam impaired the performance of the ANT rats more than that of the AT rats. The motor performance of the M rats was relatively more impaired after barbital than after lorazepam administration at the same dose used in the AT and ANT rats. At the two latter time points (2.5 and 3.5 h) the sensitive ANT rats had significantly higher serum barbital concentrations than the AT rats. The serum barbital concentrations of the AT and ANT rats did not differ, however, at the two first time points (0.5 and 1.5 h) of the tilting plane tests, although the ANT rats were significantly more intoxicated. The concentrations of lorazepam in plasma do not explain the differential motor impairment either, since the sensitive ANT rats had lower plasma concentrations than the insensitive AT rats. The results, thus, suggest that the selection involved in the development of the AT and ANT lines...Continue Reading

References

Mar 1, 1978·Psychopharmacology·B SandersC Flanagan
Jun 1, 1976·Pharmacology, Biochemistry, and Behavior·V G ErwinR A Deitrich
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·W A Hunt
Jan 1, 1982·Annual Review of Pharmacology and Toxicology·R W Olsen
Jan 1, 1983·Psychopharmacology·T C HowertonA C Collins

Citations

May 1, 1988·Pharmacology, Biochemistry, and Behavior·P KaheinenJ Ignatius
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·K Hellevuo, K Kiianmaa
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·S C Dilsaver, N E Alessi
May 1, 1989·Brain Research Bulletin·T D McIntyre, H P Alpern
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·T Petteri PiepponenLiisa Ahtee
Nov 1, 1990·The Journal of Psychology·J B Murray
Mar 1, 1991·Alcoholism, Clinical and Experimental Research·M Uusi-Oukari, E R Korpi
Apr 1, 1994·Alcoholism, Clinical and Experimental Research·D S CowleyC Godon
May 1, 1990·Pharmacology, Biochemistry, and Behavior·B CostallM B Tyers
Feb 19, 2010·Toxicology Mechanisms and Methods·Minori NishiguchiHajime Nishio
Nov 1, 1987·British Journal of Addiction·J D Sinclair
Jan 1, 1989·Annals of the New York Academy of Sciences·L Shuster
Feb 19, 2002·Neurobiology of Disease·Minnamaija LintunenPertti Panula
Nov 30, 2000·British Journal of Anaesthesia·L L FirestoneJ J Quinlan
Jan 1, 1990·The International Journal of the Addictions·L Shuster
Feb 10, 2000·Journal of Psychopharmacology·A Doble

Related Concepts

Ethanol
Veronal brand of barbital
Barbiturates
Drug Tolerance
Sedicepan
August Rats

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