Intoxication with pyrazolones

British Journal of Clinical Pharmacology
S Okonek

Abstract

1 About 50 severe or fatal (mostly accidental) cases of intoxication in children by pyrazolones have been reported in the German literature of the past 59 years. 2 Characteristic symptoms are impaired consciousness progressing to coma and convulsions. In addition, sudden apnoea and cardiac arrest may occur. Hepatic lesions may develop after a latent period of 12-24 hours. 3 Haemoperfusion seems to be the only therapeutic measure which is able to reduce the total body load of all pyrazolones to a toxicologically relevant extent. Actual clinico-toxicological data from poisoned patients are not available as yet; however, distribution volumes, plasma half-lives and endogenous plasma clearances as well as removal kinetics in vitro of aminophenazone (aminopyrine), propyphenazone, metamizole (dipyrone), phenylbutazone and oxyphenbutazone as point to the efficacy of haemoperfusion with amberlite XAD-4 resin.

References

Sep 1, 1978·Clinical Pharmacokinetics·J Aarbakke
Dec 1, 1978·Klinische Wochenschrift·H J GilfrichC J Schuster
Dec 10, 1971·Deutsche medizinische Wochenschrift·W Havers, H Stolecke
Jun 11, 1971·Deutsche medizinische Wochenschrift·H G SieberthG Siemon
Oct 1, 1980·British Journal of Clinical Pharmacology·M Volz, H M Kellner

❮ Previous
Next ❯

Citations

Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ben GoldCarl F Nathan
Sep 15, 2004·Journal of Toxicology. Clinical Toxicology·Yedidia Bentur, Omri Cohen
Jan 1, 1993·Postgraduate Medical Journal·J A Vale
Jul 18, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Karin HedenmalmRob Flynn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

© 2021 Meta ULC. All rights reserved