Intra- and extra-axonal axial diffusivities in the white matter: Which one is faster?

NeuroImage
Nicolas KunzIleana O Jelescu

Abstract

A two-compartment model of diffusion in white matter, which accounts for intra- and extra-axonal spaces, is associated with two plausible mathematical scenarios: either the intra-axonal axial diffusivity Da,‖ is higher than the extra-axonal De,‖ (Branch 1), or the opposite, i.e. Da,‖ < De,‖ (Branch 2). This duality calls for an independent validation of compartment axial diffusivities, to determine which of the two cases holds. The aim of the present study was to use an intracerebroventricular injection of a gadolinium-based contrast agent to selectively reduce the extracellular water signal in the rat brain, and compare diffusion metrics in the genu of the corpus callosum before and after gadolinium infusion. The diffusion metrics considered were diffusion and kurtosis tensor metrics, as well as compartment-specific estimates of the WMTI-Watson two-compartment model. A strong decrease in genu T1 and T2 relaxation times post-Gd was observed (p < 0.001), as well as an increase of 48% in radial kurtosis (p < 0.05), which implies that the relative fraction of extracellular water signal was selectively decreased. This was further supported by a significant increase in intra-axonal water fraction as estimated from the two-compartmen...Continue Reading

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Citations

Feb 28, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marco ReisertBibek Dhital
Nov 26, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sudhir RamannaJens H Jensen
Sep 20, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Francesco GrussuClaudia A M Gandini Wheeler-Kingshott
May 2, 2020·AJNR. American Journal of Neuroradiology·D A LakhaniF Bagnato
Oct 24, 2020·Journal of Neuroscience Methods·Dmitry S Novikov
Jul 22, 2020·Journal of Neuroscience Methods·Ileana O JelescuKurt G Schilling

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