Intra- and inter-observer agreement of brain MRI lesion volume measurements in multiple sclerosis. A comparison of techniques

Brain : a Journal of Neurology
M FilippiG Comi

Abstract

The measurement of MRI lesion load in multiple sclerosis is increasingly being used to evaluate the natural history of the disease and to monitor the efficacy of treatments. If, as might occur in multicentre studies, lesion load is measured by several observers in different patients or by the same observer in serial scans, it would be necessary to utilize a technique which provides results with high inter- and intra-observer agreements. This study was performed to evaluate the intra- and inter-observer agreement of semi-automated lesion volume measurement using thresholding, and to compare them with those obtained using an arbitrary scoring system (ASS) and a quantitative manual tracing method (MTM). Brain MRIs were obtained for 20 clinically definite multiple sclerosis patients and were evaluated independently by three observers. The median intra- and inter-observer agreements were, respectively, 88.5% (range 69.0-96.8%) and 79.0% (range 73.3-98.3%) using the ASS, 95.0% (range 85.1-99.4%) and 93.4% (range 77.3-98.3%) for the MTM, 96.3% (range 94.2-98.9%) and 93.7% (range 83.8-98.3%) for the semi-automated technique. The intra- and inter-observer agreements for the semi-automated technique increased to 98.5% (range 96.3-99.8%) ...Continue Reading

Citations

May 8, 1999·Journal of Magnetic Resonance Imaging : JMRI·C R GuttmannF A Jolesz
May 8, 1999·Journal of Magnetic Resonance Imaging : JMRI·R KikinisF A Jolesz
Jul 1, 1996·Journal of Magnetic Resonance Imaging : JMRI·C GasperiniW I McDonald
Nov 23, 2006·Surgical and Radiologic Anatomy : SRA·Abdullah TarrounFrançois Cotton
Feb 22, 2002·Journal of Neuroscience Methods·Paula GadebergJohannes Jakobsen
Oct 12, 2000·Magnetic Resonance Imaging·M RovarisM Filippi
Jun 11, 1998·Magnetic Resonance Imaging·D Goldberg-ZimringH Azhari
May 7, 1999·Magnetic Resonance Imaging·M J FirbankE D Williams
Jul 5, 2001·The Australian and New Zealand Journal of Psychiatry·J L RapoportP Nelson
Jun 21, 2012·Physics in Medicine and Biology·Abhinav K JhaAlison T Stopeck
Jun 25, 2003·Investigative Radiology·Nancy L SicotteJohn C Mazziotta
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D H Miller, A J Thompson
May 9, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Niels GeerdinkReinier A Mullaart
Dec 1, 1996·Italian Journal of Neurological Sciences·M FilippiG Comi
Apr 22, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P D Molyneux H
Jul 29, 1998·Journal of Medical Engineering & Technology·T HeinonenE Laasonen
Dec 17, 2015·Journal of the Neurological Sciences·Paulo Afonso MeiFabiano Reis
Aug 16, 2011·NeuroImage·Bennett A LandmanJerry L Prince
Apr 6, 2006·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Jayaram K UdupaJames Woodburn
Dec 31, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Lifeng LiuCharles R G Guttmann
Oct 2, 2012·Journal of Magnetic Resonance Imaging : JMRI·Shuangxi JiJing Fang
Jan 24, 2015·IEEE Transactions on Medical Imaging·Xavier Tomas-Fernandez, Simon K Warfield
Feb 5, 2005·Academic Radiology·Jan RexiliusHeinz-Otto Peitgen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.