PMID: 8582352Sep 1, 1995Paper

Intra- and inter-population diversity at short tandem repeat loci in diverse populations of the world

Electrophoresis
R DekaR Chakraborty

Abstract

To study the level of intra- and inter-population variation at hypervariable DNA loci, we have characterized 15 human populations of diverse ethnic and geographic origins at six short tandem repeat loci by using the polymerase chain reaction. Even though the spectrum of allelic variation is quite broad and there are substantial differences in allele frequency distributions among populations, in general, population within a major racial group show a greater degree of similarity. This observation is reflected in the analysis of gene diversity. When the total diversity is apportioned, the maximum variation becomes attributable to inter-individual differences within a population; of the variation that is attributed to differences between populations within a racial group and differences between racial groups, namely, African, Caucasian, and Mongoloid, than the American Indians and the Pacific Islanders. As expected, a reciprocal relationship between gene diversity and FST levels is observed. Higher values of FST in the American Indian and the Pacific Islanders may reflect smaller population size and a higher level of isolation. An analysis of genetic distance encompassing the populations belonging to the three major racial groups r...Continue Reading

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Citations

Jun 1, 1997·American Journal of Physical Anthropology·M C BortoliniT de A Weimer
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L B JordeA R Rogers
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Oct 9, 2001·American Journal of Physical Anthropology·R González-JoséH M Pucciarelli
Apr 22, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·V K KashyapT S Vasulu
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Jun 1, 1997·Genome Research·M D ShriverR Deka
Oct 24, 2020·International Journal of Molecular Sciences·Marcela Suárez-EsquivelCaterina Guzmán-Verri

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