PMID: 3191938Jan 1, 1988Paper

Intra- and inter-subject variation in the pharmacokinetics of indoramin and its 6-hydroxylated metabolite

European Journal of Clinical Pharmacology
D M PierceR A Franklin


Intra- and inter-subject variation in the kinetics of indoramin and its active metabolite 6-hydroxyindoramin have been studied in 5 young, healthy, male volunteers administered a single oral dose of the drug on 5 separate occasions. Inter-subject variation represented the main source of variability in indoramin plasma concentrations with, for example, the between-subjects sum of squares (a measure of the contribution to the total variability) representing around 97% of the total sum of squares for Cmax and AUC (0-24). Intra-subject and inter-subject coefficients of variation (C.V.s) were circa 20% and 100% respectively for both these parameters. Variability in 6-hydroxyindoramin concentrations was much lower and was approximately equally derived from intra- and inter-subject variation, with the C.V.s being approximately 44% for both Cmax and AUC (0-24). The results imply that the kinetic behaviour of indoramin within an individual will prove relatively consistent, despite widespread inter-subject variation, once an appropriate dosage regime has been established.


Jun 1, 1976·British Journal of Clinical Pharmacology·G H DraffanC T Dollery
Mar 1, 1988·Biopharmaceutics & Drug Disposition·D M PierceR A Franklin
Jan 1, 1987·European Journal of Clinical Pharmacology·D M PierceR A Franklin
Jan 1, 1984·European Journal of Clinical Pharmacology·H M NorburyS J Warrington
Jan 1, 1983·European Journal of Clinical Pharmacology·H M NorburyS J Warrington
Jan 1, 1982·Current Medical Research and Opinion·G N VolansT Frost

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Dec 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D M Pierce

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