Intra- and interobserver reproducibility of left ventricular mechanical dyssynchrony assessment by real time three-dimensional echocardiography

Echocardiography
Cesare RussoMarco R Di Tullio

Abstract

Real time three-dimensional (3D) echocardiography allows the assessment of left ventricular (LV) mechanical dyssynchrony and may be useful in predicting response to cardiac resynchronization therapy. However, reproducibility of 3D dyssynchrony in past reports varied widely. We evaluated intra- and interobserver reproducibility of parameters of LV mechanical dyssynchrony by 3D echocardiography and explored the impact of image quality as a possible source of variability. LV volumes and ejection fraction (LV EF) were measured by 3D echocardiography in 90 subjects. LV mechanical dyssynchrony was calculated as the standard deviation of the time-to-minimum segmental volume (Tmsv) over 16 (SDI16) and 12 (SDI12) segments and as the maximum time-difference in Tmsv over 16 (Dif16), 12 (Dif12), and 2 (DifS-L) segments. Opposing wall delay in peak myocardial systolic velocity (S-L delay) by tissue Doppler imaging (TDI) was also evaluated. Feasibility of 3D measurements was 88.9%. Intra- and interobserver intraclass correlation coefficients were excellent for LV volumes, LV EF, and S-L delay (all ≥ 0.90), very good for SDI16 (0.83 and 0.85), moderate to good for SDI12, Dif16, Dif12, and DifS-L (0.51-0.81). No systematic bias was present bet...Continue Reading

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Citations

Sep 3, 2013·Current Opinion in Critical Care·Nicole M Bhave, Roberto M Lang
Sep 24, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Wendy TsangMark Monaghan
Aug 31, 2013·Circulation Research·Jonathan A Kirk, David A Kass
Nov 27, 2019·Expert Review of Cardiovascular Therapy·Andrada C GutaDenisa Muraru
Oct 19, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Erica O MillerRonald G Schwartz

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