Intra- and Interspecies Effects of Outer Membrane Vesicles from Stenotrophomonas maltophilia on β-Lactam Resistance

Antimicrobial Agents and Chemotherapy
Simon DevosBart Devreese

Abstract

The treatment ofStenotrophomonas maltophiliainfection with β-lactam antibiotics leads to increased release of outer membrane vesicles (OMVs), which are packed with two chromosomally encoded β-lactamases. Here, we show that these β-lactamase-packed OMVs are capable of establishing extracellular β-lactam degradation. We also show that they dramatically increase the apparent MICs of imipenem and ticarcillin for the cohabituating speciesPseudomonas aeruginosaandBurkholderia cenocepacia.

References

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Citations

Oct 26, 2016·Cellular Microbiology·Nichole Orench-Rivera, Meta J Kuehn
Jul 28, 2018·FEMS Microbiology Letters·Vladislav M ChernovMaxim V Trushin
Mar 27, 2020·Frontiers in Cellular and Infection Microbiology·Christian Rueter, Martina Bielaszewska
Dec 29, 2020·Frontiers in Microbiology·Negar Mozaheb, Marie-Paule Mingeot-Leclercq
Apr 16, 2021·Advanced Drug Delivery Reviews·Robert Richter, Claus-Michael Lehr
May 28, 2021·Clinical Microbiology Reviews·Joanna S Brooke
Jul 27, 2021·Antimicrobial Agents and Chemotherapy·Carolina LópezAlejandro J Vila

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