Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures

Brain Research
M H PourgholamiMohammad Reza Palizvan

Abstract

The seizure-modulating effects of 2-chloroadenosine (2-CLA) infused directly into the amygdala were investigated. Different groups of amygdala-kindled rats were infused (1 microliter) with 2-CLA (0.25, 1, 10 and 25 nM), caffeine (200 microM and 2 mM), a combination of the two or artificial cerebrospinal fluid (ACSF) applied directly through a cannula located in the amygdala. Infusion of 2-CLA dramatically suppressed seizure stage (SS), after discharge duration (ADD) and stage 5 seizure duration (S5D), while the latency to bilateral forelimb clonus (S4L) was significantly prolonged. These anticonvulsant effects were evident after 5 min, reached a maximum at the 60 min time point and were still detectable 360 min post-2-CLA infusion. Pretreatment with caffeine blocked the anticonvulsant effects of 2-CLA dose-dependently. These results may suggest that in amygdaloid-kindled rats, adenosine receptors located in the amygdala play a major role in the expression of the anticonvulsant activity of 2-CLA.

Citations

Nov 18, 2006·Canadian Journal of Physiology and Pharmacology·Parviz ShahabiAli Eslami-far
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Mohammad Ebrahim RezvaniMohammad Reza Palizvan
Jun 26, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Simin NamvarMaryam Zeraati
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Juan A Barcia, José M Gallego
Aug 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick M KochanekEdwin K Jackson
Jun 3, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick M KochanekChien Ho
Dec 2, 2020·Pharmaceutics·Manuela Gernert, Malte Feja
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Eric SouthamPhilip F Morgan
Jul 12, 2005·Epilepsy Research·Mohammad Mohammad-ZadehYaghoub Fathollahi

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