Intra-amygdalar injection of DAMGO: effects on c-Fos levels in brain sites associated with feeding behavior

Brain Research
Allen S LevineC J Billington

Abstract

It is well known that the mu opioid agonist, Tyr-D-Ala-Gly-(me) Phe-Gly-ol (DAMGO), increases food intake in rats when injected into a variety of brain sites including the central nucleus of the amygdala (CeA). Immunohistochemical studies measuring c-Fos immunoreactivity (IR) suggest that the CeA contributes to opioid-related feeding. In the current study, we injected 2 nmol of DAMGO and measured food intake, c-Fos IR levels in various brain sites involved in feeding behavior, and mu opioid receptor internalization. We also studied the effect of CeA-injected DAMGO on LiCl-induced increases in c-Fos IR in the amygdala. As was expected, intra-CeA injection of DAMGO increased food intake of rats over a 4-h period. DAMGO injection into the CeA also resulted in mu opioid receptor internalization in the CeA, indicating activation of mu opioid receptor expressing neurons in this site. Administration of DAMGO into the CeA increased c-Fos IR levels in the shell of the nucleus accumbens (NAcc), but not in 17 other brain sites that were studied. We also found that intra-CeA injection of DAMGO, prior to LiCl injection, decreased c-Fos IR levels in the CeA compared to vehicle-injected rats. Thus, intra-CeA administration of DAMGO may increa...Continue Reading

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Citations

Dec 15, 2011·Psychopharmacology·Stephen V Mahler, Kent C Berridge
Jun 6, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dianne P FiglewiczAlfred J Sipols
May 4, 2011·Physiology & Behavior·Pawel K OlszewskiAllen S Levine
Jul 7, 2010·Physiology & Behavior·G-Q ChangS F Leibowitz
Oct 6, 2009·Physiology & Behavior·Amanda Alcaraz da SilvaMarta Aparecida Paschoalini
Jan 13, 2009·Physiology & Behavior·Tiffany R BeckmanCharles J Billington
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Dec 21, 2005·Brain Research Reviews·Daniela CotaAllen S Levine
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Jul 7, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Juliana L GiacominiBrian A Baldo

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