Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion

Acta Cirúrgica Brasileira
Zoltan KlarikNorbert Nemeth

Abstract

To examine how the ischemia-reperfusion injury of latissimus dorsi-cutaneous maximus (LDCM) musculocutaneous flap affects the microcirculatory (flap's skin surface) and hemorheological parameters, and whether an intraoperative deterioration would predictively suggest flap failure in the postoperative period. Ten healthy male rats were subjected to the study. In Group I the left flap was sutured back after 2-hour, while the contralateral side was right after its elevation. In Group II the same technique was applied, but the pedicle of the left flap was atraumatically clamped for 2-hour. The contralateral side was left intact. On the flap skin surface laser Doppler tissue flowmetry measurements were done before and after and during the protocols applied in the groups. Microcirculatory and hemorheological examinations were done postoperatively. The microcirculatory parameters significantly decreased during immobilization and ischemia. Afterwards, all the regions showed normalization. In the retrospective analysis there was a prominent difference between the microcirculatory parameters of necrotic and survived flap during the early postoperative days (1-3) in Group II. Erythrocyte aggregation and deformability showed only slight di...Continue Reading

References

May 1, 1991·Journal of Biomedical Engineering·T J Essex, P O Byrne
Sep 1, 1990·Journal of Medical Engineering & Technology·A N ObeidG Ward
Apr 1, 1982·British Journal of Plastic Surgery·B M Jones, B J Mayou
Jan 1, 1993·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·D Hellner, R Schmelzle
Nov 22, 2001·Annals of Plastic Surgery·K Islamoglu, E Ozgentas
Jan 25, 2003·Annals of Plastic Surgery·Sadanori InoueYasuaki Kawai
Feb 11, 2003·The British Journal of Oral & Maxillofacial Surgery·J S BrownE D Vaughan
Oct 15, 2003·Microsurgery·Norbert NemethIren Miko
Nov 25, 2003·Seminars in Thrombosis and Hemostasis·Oguz K Baskurt, Herbert J Meiselman
Sep 21, 2004·Microsurgery·Maria Siemionow, Emrah Arslan
Feb 5, 2005·Plastic and Reconstructive Surgery·Jeri R PayetteMichael G Sowa
Nov 1, 2005·The Journal of Surgical Research·Attila SzijártóPéter Károly Kupcsulik
Apr 22, 2009·Microsurgery·Matthias ReichenbergerHolger Engel
May 13, 2009·Clinical Hemorheology and Microcirculation·Oguz K BaskurtUNKNOWN International Expert Panel for Standardization of Hemorheological Methods
Jan 9, 2010·Plastic and Reconstructive Surgery·Christopher J SalgadoSamir Mardini
Sep 3, 2010·The Canadian Journal of Plastic Surgery = Journal Canadien De Chirurgie Plastique·Paul PapillionJason Rehm
Apr 1, 2011·Annals of Plastic Surgery·Feng Zhang, William Lineaweaver
Jun 15, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·R KraemerP M Vogt
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Jan 24, 2013·Clinical Hemorheology and Microcirculation·Norbert NemethIren Miko
Jan 24, 2013·Clinical Hemorheology and Microcirculation·Norbert NemethIren Miko
Jun 3, 2014·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·Albert H Chao, Susan Lamp

❮ Previous
Next ❯

Citations

Apr 18, 2018·Clinical Hemorheology and Microcirculation·Laura PetrovicsGabor Jancso
May 28, 2017·Clinical Hemorheology and Microcirculation·Zsuzsanna MagyarNorbert Nemeth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.