PMID: 6106094Aug 30, 1980Paper

Intra-arterial chemotherapy as basal treatment in advanced and fungating primary breast cancer

Lancet
F O StephensC K Hambly

Abstract

Occasionally patients present with stage III breast carcinoma so advanced that local radiotherapy is unlikely to achieve more than a partial and temporary local regression. 3 such patients with grossly advanced cancer involving virtually the whole of the breast, skin, and underlying muscle were treated with a regimen of intra-arterial infusion chemotherapy as basal treatment before planned irradiation. All 3 patients responded significantly to intra-arterial chemotherapy and subsequent definitive radiotherapy seems to have resulted in total regression of tumour and involved nodes in 2 patients. In the 3rd patient the response of the tumour mass to subsequent radiotherapy was considerable but incomplete; subsequent surgical resection seems to have eradicated the small foci of residual disease buried in fibrous tissue in the breast and one axillary node. All patients were given routine adjuvant chemotherapy after completion of irradiation. A 4th patient with a huge fungating breast carcinoma which was bleeding and foul-smelling who also had evidence of liver metastasis (stage IV disease) was treated in a similar manner. Local tumour regression was achieved and although the patient still requires treatment for metastatic disease t...Continue Reading

References

Jun 1, 1979·The Australian and New Zealand Journal of Surgery·F O StephensB A Roberts
Dec 1, 1979·The Australasian Journal of Dermatology·F O Stephens, G J Harker
Jan 1, 1978·Journal of Surgical Oncology·D J Jussawalla, P A Shetty
Feb 19, 1976·The New England Journal of Medicine·G BonadonnaU Veronesi
Jul 1, 1954·The Journal of the Faculty of Radiologists·S MUSTAKALLIO

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Citations

Jan 1, 1990·Cancer Chemotherapy and Pharmacology·C J TwelvesR D Rubens
Oct 13, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M NagasawaY Morishita
Mar 1, 1981·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A N Papaioannou
Mar 28, 1981·Lancet
Sep 1, 1992·The Australian and New Zealand Journal of Surgery·F O StephensF W Marsden
Jun 1, 1981·Postgraduate Medical Journal·H Ellis
Jan 1, 1990·Acta Oncologica·A Wallgren
Jan 1, 1985·Cancer Drug Delivery·H J Keizer, H M Pinedo
May 1, 1990·Acta Anaesthesiologica Scandinavica·L O JonssonR Lee
Oct 1, 1982·Acta Anaesthesiologica Scandinavica·J Hovorka
Apr 1, 1990·Acta Anaesthesiologica Scandinavica·L O Jonsson
May 1, 1989·Acta Anaesthesiologica Scandinavica·L O Jonsson, C Wahlgreen
Mar 1, 1994·Journal of Neurosurgery·R L MacdonaldT J Coyne
Sep 11, 2014·World Journal of Gastroenterology : WJG·Toshifusa Nakajima, Masashi Fujii
Nov 5, 1997·American Journal of Clinical Oncology·H T ChangW S Tzeng
Mar 1, 1992·Journal of Surgical Oncology·S T BrowerJ Camunas
Feb 4, 1984·The Medical Journal of Australia·F O StephensP Crea
Dec 2, 1991·The Medical Journal of Australia·F O StephensL D Watson

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