Intra-arterial chemotherapy for retinoblastoma: Two-year results from tertiary eye-care center in India

Indian Journal of Ophthalmology
Pukhraj RishiSatheesh Ramamurthy

Abstract

The aim of this study is to describe treatment outcomes and complications of selective intra-arterial chemotherapy (IAC) for intraocular retinoblastoma (RB). A retrospective, interventional series of 10 eyes with RB which underwent IAC using melphalan (5 mg/7.5 mg) and topotecan (1 mg), or melphalan (5 mg/7.5 mg) alone. Treatment outcomes were evaluated in terms of tumor control, vitreous seeds (VS) and subretinal seeds (SRS) control, and globe salvage rates. Ten eyes of 10 patients underwent 38 IAC sessions (mean = 3.8; median = 4; range = 3-5 sessions). Following IAC, complete regression of main tumor was seen in 9 eyes (90%) and partial regression in 1 (10%). All four eyes with SRS showed complete regression (100%). Of 5 eyes with VS, 3 eyes (60%) showed complete regression, 1 eye (20%) showed relapse, while 1 eye (20%) showed no response. Globe salvage was achieved in 8 of 10 eyes (80%). Complications included transient ophthalmic artery narrowing (n = 2), branched retinal vein occlusion (n = 1), forehead skin pigmentation (n = 1), and vitreous hemorrhage (n = 2). There was no case of stroke, hemiplegia, metastasis, or death. Transient hematological changes included relative pancytopenia (n = 4), relative leukopenia (n = 5)...Continue Reading

References

Nov 1, 1958·A.M.A. Archives of Ophthalmology·A B REESEA W FORREST
Nov 5, 2011·The British Journal of Ophthalmology·David H AbramsonY Pierre Gobin
Jun 15, 2012·The British Journal of Ophthalmology·Francis L MunierMaja Beck-Popovic
Oct 10, 2012·Archives of Ophthalmology·Fariba Ghassemi, Carol L Shields
Apr 2, 2015·Indian Journal of Ophthalmology·Swathi Kaliki, Carol L Shields
Jun 6, 2015·Indian Journal of Ophthalmology·Pukhraj RishiSatheesh Ramamurthy
Jun 23, 2016·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Emil Anthony T SayCarol L Shields

❮ Previous
Next ❯

Citations

May 20, 2019·Journal of Neurointerventional Surgery·Krishnan RavindranWaleed Brinjikji
Nov 23, 2019·Indian Journal of Ophthalmology·David A CampCarol L Shields
Mar 26, 2019·International Ophthalmology Clinics·Arun D Singh
Apr 8, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J RunnelsB Fiani
Feb 1, 2020·Ocular Oncology and Pathology·Pukhraj RishiR Ravikumar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.