PMID: 6538237Feb 1, 1984Paper

Intra-arterial cisplatin treatment of unresectable or medically inoperable invasive carcinoma of the bladder

The Journal of Urology
D J StewartP Rasuli

Abstract

Five patients between 72 and 82 years old received 5 to 6 treatments of 50 to 75 mg. per m.2 cisplatin by bilateral internal iliac artery infusion for unirradiated invasive transitional cell carcinoma of the bladder. Of the patients 3 also were diabetics and 1 had congestive heart failure. Treatment was tolerated extremely well, although most courses were associated with moderate to severe nausea and vomiting lasting several hours. Of 4 evaluable patients 3 achieved complete remission and 1 achieved a good partial remission. An additional 55-year-old woman with a large invasive bladder carcinoma fixed to surrounding structures was treated with 4 courses of 100 mg. per m.2 intra-arterial cisplatin. This patient had a marked decrease in tumor size, permitting surgical resection of all known residual tumor. A 49-year-old patient with large pelvic lymph node metastases from a squamous cell carcinoma of the bladder achieved only minimal decrease in tumor size after 3 courses of 100 mg. per m.2 intra-arterial cisplatin. We conclude that intra-arterial cisplatin can be highly effective for localized invasive bladder cancer even when relatively low doses are used. With proper care the regimen can be used safely and effectively in elder...Continue Reading

References

Nov 1, 1978·International Journal of Radiation Oncology, Biology, Physics·E K ReddyC M Mansfield
Jan 1, 1984·Progress in Experimental Tumor Research·D J Stewart
Mar 1, 1982·Cancer·J A SmithW F Whitmore
Nov 1, 1982·Cancer·B NeedlesW F Whitmore
Dec 1, 1982·Cancer Chemotherapy and Pharmacology·D J StewartT L Loo
Nov 1, 1982·Urology·J H DeWeerdR E Cupps

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Citations

Jan 1, 1992·International Urology and Nephrology·P K SahaY Saito
Jan 1, 1997·Acta Oncologica·A MokarimH Ohtani
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·Y SumiyoshiS Kagawa
Aug 1, 1987·The Journal of Urology·D J StewartW K Evans
Jul 1, 1989·Journal of Surgical Oncology·D S Menashe, S C Jacobs
Jan 15, 1994·International Journal of Radiation Oncology, Biology, Physics·D J StewartG P Raaphorst

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