PMID: 7747999Apr 1, 1995Paper

Intra-arterial infusion chemotherapy for advanced or recurrent breast cancers

Gan to kagaku ryoho. Cancer & chemotherapy
M OkazakiE Narimatsu


Ideally, in preoperative intra-arterial infusion chemotherapy (regarding advanced breast cancer) is to obtain the most significant effects concerning histological features. Intra-arterial infusion chemotherapy using epirubicin (EPI), used in conjunction with daily doses of 1,200 mg medroxyprogesterone acetate (MPA), have recently been performed. This procedure has shown remarkable histological effects in the metastatic lymph nodes as well as in the primary lesions. These results were especially remarkable in the patients who were administered MPA (daily) two weeks prior to EPI infusion. These patients showed a complete disappearance of tumor cells. The results were interesting in view of the mechanism of action. Intra-arterial infusion chemotherapy combined with MPA may also be valuable in treating metastatic liver tumors and recurrent lesions in the regional lymph nodes such as supraclavicular tumors. A high response rate was obtained in the chemo-endocrine therapy when combined with MPA as a pretreatment. Thus, MPA may be expected to be available as a systemic therapy, too. In the future, a new development in the field of intra-arterial infusion chemotherapy may be achieved by utilizing a combination of angiogenesis inhibitor...Continue Reading

Related Concepts

Pirarubicin hydrochloride
Antineoplastic Chemotherapy Protocols
Mammary Neoplasms, Human
Drug Administration Schedule
Infusions, Regional Arterial
Lymphatic Metastasis
Neoplasm Recurrence, Local
Remission Induction

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