PMID: 1019574Nov 1, 1976Paper

Intra-arterial infusion of prostaglandin E1 in normal subjects and patients with peripheral arterial disease

Scandinavian Journal of Clinical and Laboratory Investigation
P E NielsenN A Lassen


Acute vasodilatation was produced by infusion of prostaglandin E1 (PGE1) in the femoral artery in 6 patients with occlusive arterial disease of the legs and in 3 normal subjects. The effect on blood flow and on blood pressure was measured at different segments of the leg with the strain gauge technique, isotope clearance technique, and photoelectric technique. Skin temperature was measured at different levels by using thermocouples. The blood pressure on the legs decreased at all segments during vasodilatation as well in patients as in controls. The blood flow increased in all segments in normal controls. In patients the blood flow increased proximally in the legs. Distally, however, no increase could be demonstrated. As a good effect of PGE1, on ischaemic rest pains has been reported, mechanisms other than vasodilatation should probably be considered.


Jul 1, 1972·The American Journal of Medicine·C B Higgins, E Braunwald
Feb 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·F GyntelbergH L Poulsen
Jun 1, 1969·Scandinavian Journal of Clinical and Laboratory Investigation·S Bevegård, L Orö
Jan 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·P Astrup
Jun 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·I Dahn, T Hallböök
Jan 1, 1969·Acta Physiologica Scandinavica·L A CarlsonL Orö
Oct 11, 1952·British Medical Journal·J W L EDWARDSD C WATSON
Feb 24, 1962·British Medical Journal·G W TAYLOR, A R CALO
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·P E NielsenN A Lassen


May 1, 1983·World Journal of Surgery·B J Pardy, H H Eastcott
Dec 1, 1986·Journal of the American College of Cardiology·H BounameauxM Verstraete
Aug 1, 1981·Annals of the Rheumatic Diseases·M F MartinJ D Kirby
Oct 18, 1980·British Medical Journal·P C CliffordP A Dieppe
Jul 1, 1979·Progress in Cardiovascular Diseases·J D Coffman
Dec 1, 1986·European Journal of Clinical Investigation·A CreutzigK Alexander
Jun 1, 1989·The Journal of Urology·T I HwangH C Wu
May 20, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·S M SchellongK Alexander
Dec 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·P E Nielsen
Nov 1, 1976·Stroke; a Journal of Cerebral Circulation·J Olesen

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